Hussain Rabia, Hassali Mohamed Azmi, Hashmi Furqan, Akram Tayyaba
Commonwealth Pharmacists Association, London, E1W 1AW, UK.
Faculty of Pharmacy, The University of Lahore, Lahore, 54590, Pakistan.
J Pharm Policy Pract. 2021 Jan 4;14(1):5. doi: 10.1186/s40545-020-00287-3.
Spontaneous reporting of adverse drug reactions (ADRs) is a method of monitoring the safety of drugs and is the basic strategy for the post-marketing surveillance of the suspected drugs. Despite its importance, there is very little reporting of ADRs by healthcare professionals. The present study has evaluated the knowledge, attitude and practices of health care professionals (HCPs) regarding pharmacovigilance activities in Lahore, Pakistan.
A cross-sectional questionnaire-based survey was employed, and a convenience sampling was opted to collect the data among physicians, pharmacists and nurses working in tertiary care public hospitals of Lahore, Pakistan from September 2018 to January 2019.
Of the 384 questionnaires distributed, 346 health care professionals responded to the questionnaire (90.10% response rate). Most participants had good knowledge about ADR reporting, but pharmacist had comparatively better knowledge than other HCPs regarding ADR (89.18%) pharmacovigilance system (81.08%), its centres (72.97%) and function (91.89%). Most of the participants exhibited positive attitude regarding ADR reporting, such as 49.1% of physicians (P < 0.05), 70.2% pharmacists and 76.1% nurses showed a positive attitude that they are the most important HCPs to report an ADR. About 64.3% of physicians (P < 0.05) emphasized that consulting other colleagues is important before reporting an ADR. Of all, 77.7% physicians, 75.7% pharmacists and 68% of nurses had positive attitude that ADR reporting is a professional obligation and 67.6% of the pharmacists stated that they have reported ADRs in their workplace and 77.2% nurses have verbally reported ADRs to the concerned personnel or department.
Among all HCPs, pharmacists had better knowledge about ADR reporting and pharmacovigilance. All HCPs had positive attitude and inclination towards ADR reporting. The discrepancies were observed in the practices related to ADR reporting, whereas most of the participants including physicians and nurses did not report any ADR. Based on the above, strategies are needed to educate, train, and empower the HCPs in the domain of pharmacovigilance.
药品不良反应（ADR）的自发报告是监测药物安全性的一种方法，也是对可疑药物进行上市后监测的基本策略。尽管其很重要，但医疗保健专业人员对ADR的报告却非常少。本研究评估了巴基斯坦拉合尔医疗保健专业人员（HCPs）在药物警戒活动方面的知识、态度和实践情况。
采用基于问卷调查的横断面研究方法，通过便利抽样，于2018年9月至2019年1月在巴基斯坦拉合尔的三级公立医疗机构工作的医生、药剂师和护士中收集数据。
在分发的384份问卷中，346名医疗保健专业人员回复了问卷（回复率为90.10%）。大多数参与者对ADR报告有较好的了解，但药剂师在ADR（89.18%）、药物警戒系统（81.08%）、其中心（72.97%）和功能（91.89%）方面的知识比其他HCPs相对更好。大多数参与者对ADR报告表现出积极态度，例如49.1%的医生（P<0.05）、70.2%的药剂师和76.1%的护士表示他们是报告ADR的最重要的HCPs。约64.3%的医生（P<0.05）强调在报告ADR之前咨询其他同事很重要。总体而言，77.7%的医生、75.7%的药剂师和68%的护士认为ADR报告是一项职业义务，67.6%的药剂师表示他们在工作场所报告过ADR，77.2%的护士已将ADR口头报告给相关人员或部门。
在所有HCPs中，药剂师对ADR报告和药物警戒有更好的了解。所有HCPs对ADR报告都持积极态度和倾向。在与ADR报告相关的实践中存在差异，而包括医生和护士在内的大多数参与者都没有报告任何ADR。基于以上情况，需要在药物警戒领域对HCPs进行教育、培训和赋能的策略。
