Batista Julia Arruda, Wakayama Bruno, Freitas Rayara Nogueira de, Fiais Gabriela Alice, Chaves-Neto Antonio Hernandes, Saliba Tânia Adas, Garbin Artênio José Isper, Garbin Clea Adas Saliba
Universidade Estadual Paulista - Unesp, School of Dentistry of Araçatuba, Department of Preventive and Restorative Dentistry, Araçatuba, SP, Brazil.
Universidade Estadual Paulista - Unesp, School of Dentistry of Araçatuba, , Department of Basic Sciences, Araçatuba, SP, Brazil.
Braz Oral Res. 2025 May 12;39:e053. doi: 10.1590/1807-3107bor-2025.vol39.053. eCollection 2025.
This study aimed to investigate oral conditions and their impact on salivary biochemical parameters in institutionalized individuals with and without substance use disorder. This was an epidemiological, cross-sectional, and clinical study. It included two groups, institutionalized individuals with substance use disorder (SUD group) and without substance use disorder (control group), each consisting of 60 participants. Salivary samples were analyzed for various parameters, while oral conditions were assessed using the DMFT index, community periodontal index, clinical attachment loss index, and need for prosthesis. Statistical analysis included the Mann-Whitney U test, t-tests, and correlation analysis (p ≤ 0.050). The SUD group showed a higher need for dental prostheses (p < 0.001) and more pronounced dental erosion (p < 0.001). This group also exhibited elevated DMFT indices, with significant associations in sextants with calculus (p = 0.010), periodontal pockets (p < 0.001), and attachment loss of 12 mm or more (p = 0.036). Regarding salivary parameters, the SUD group had high cortisol levels and significant correlations between uric acid and bleeding sextants (p = 0.024), salivary amylase and decayed teeth (p = 0.002), cortisol and the DMFT index (p = 0.045), and cortisol and the absence of DMFT (p = 0.042). In conclusion, individuals in the SUD group exhibited worse oral conditions than did those in the control group, suggesting a relationship between drug addiction and increased cortisol, uric acid, and salivary amylase levels.
本研究旨在调查有无物质使用障碍的机构化照护个体的口腔状况及其对唾液生化参数的影响。这是一项流行病学、横断面和临床研究。研究包括两组，有物质使用障碍的机构化照护个体（SUD组）和无物质使用障碍的个体（对照组），每组各有60名参与者。对唾液样本进行了各种参数分析，同时使用DMFT指数、社区牙周指数、临床附着丧失指数和义齿需求来评估口腔状况。统计分析包括曼-惠特尼U检验、t检验和相关性分析（p≤0.050）。SUD组义齿需求更高（p<0.001），牙齿侵蚀更明显（p<0.001）。该组还表现出DMFT指数升高，在有牙结石的牙象限（p = 0.010）、牙周袋（p<0.001）和附着丧失12毫米或以上（p = 0.036）方面存在显著关联。关于唾液参数，SUD组皮质醇水平较高，尿酸与出血牙象限之间存在显著相关性（p = 0.024），唾液淀粉酶与龋牙之间存在显著相关性（p = 0.002），皮质醇与DMFT指数之间存在显著相关性（p = 0.045），皮质醇与无DMFT之间存在显著相关性（p = 0.042）。总之，SUD组个体的口腔状况比对照组个体更差，这表明药物成瘾与皮质醇、尿酸和唾液淀粉酶水平升高之间存在关联。
