Łojek Paula, Rzeszutek Marcin
Department of Child Psychiatry, Medical University of Warsaw, Żwirki I Wigury 63A, 02-091 Warsaw, Poland.
Department of Child Psychiatry, Medical University of Warsaw, Żwirki I Wigury 63A, 02-091 Warsaw, Poland.
J Psychiatr Res. 2025 Jul;187:144-153. doi: 10.1016/j.jpsychires.2025.05.001. Epub 2025 May 8.
This article aims to describe the symptomatology of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), and to highlight some of their potential distinctive features, by juxtaposing available data with existing literature on pediatric obsessive - compulsive disorder (OCD). Given the scarcity of high-quality studies, we decided to review a wide range of publications on the clinical presentation of PANS and PANDAS, including case series and case reports, regardless of their methodological heterogeneity. Although PANS and PANDAS share many characteristics with non-PANS/PANDAS OCD, the acute onset of obsessive-compulsive symptoms in conjunction with concomitant features, especially separation anxiety, irritability, emotional lability, or dysgraphia should prompt consideration of a possible post-infectious etiology. Further research aimed at creating more precise diagnostic tools is needed to facilitate differential diagnosis.
本文旨在描述与链球菌感染相关的儿童自身免疫性神经精神障碍（PANDAS）和儿童急性起病神经精神综合征（PANS）的症状学，并通过将现有数据与关于儿童强迫症（OCD）的现有文献并列，突出它们的一些潜在独特特征。鉴于高质量研究的匮乏，我们决定回顾大量关于PANS和PANDAS临床表现的出版物，包括病例系列和病例报告，无论其方法学上的异质性如何。尽管PANS和PANDAS与非PANS/PANDAS强迫症有许多共同特征，但强迫症状的急性发作以及伴随特征，尤其是分离焦虑、易怒、情绪不稳定或书写障碍，应促使考虑可能的感染后病因。需要进一步开展旨在创建更精确诊断工具的研究，以促进鉴别诊断。
