煤油对豚鼠气道对卵清蛋白致敏作用的影响。

Effects of kerosene on airway sensitization to egg albumin in guinea pig.

作者信息

Casacó A, Carvajal D, Noa M, González R, García M, Rodríguez de la Vega A

出版信息

Allergol Immunopathol (Madr). 1985 May-Jun;13(3):235-9.

Abstract

We undertook a study to determine if pre-exposure to kerosene smoke enhances airway sensitization to egg albumin in the guinea pig. Kerosene vapor inhalation for 15 days, 1 hour daily, in similar conditions to which some housewives who use kerosene as cooking fuel are exposed elicited tracheal damage characterized by signs of dysplasia and inflammatory infiltrate. When these animals were exposed to egg albumin aerosol there was an increase in the antialbumin antibody blood titer and an increased response to egg albumin in the isolated tracheal preparation (Schultz-Dale reaction), We conclude that the airway damage elicited by inhalation of kerosene vapor increase antigen absorption and thereby antibody formation.

摘要

我们进行了一项研究，以确定预先暴露于煤油烟雾是否会增强豚鼠气道对卵清蛋白的致敏性。在与一些使用煤油作为烹饪燃料的家庭主妇所接触的类似条件下，每天1小时，持续15天吸入煤油蒸汽，引发了气管损伤，其特征为发育异常和炎性浸润迹象。当这些动物暴露于卵清蛋白气雾剂时，抗白蛋白抗体血滴度增加，并且在离体气管制剂中对卵清蛋白的反应增强（舒尔茨-戴尔反应）。我们得出结论，吸入煤油蒸汽引起的气道损伤会增加抗原吸收，从而促进抗体形成。