Alderete Isaac S, Soto Alexandria L, Halpern Samantha E, Pontula Arya, Muylle Ewout, Nakata Kentaro, Patel Kunal J, Klapper Jacob, Hartwig Matthew G
Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Am J Transplant. 2025 May 12. doi: 10.1016/j.ajt.2025.05.011.
Short-statured lung transplant candidates experience longer waitlist times than taller ones. The new composite allocation score (CAS) includes height to enhance allocation equity. We assessed the impact of CAS on waitlist outcomes for different height groups. We queried a national transplant database for lung transplant candidates listed from 2021 to 2024, categorized into 4 height groups: ≤162 cm, 162 to 170 cm, 170 to 176.5 cm, and >176.5 cm. Competing risk and Cox regression models assessed the impact of height on waitlist outcomes, including an interaction term between height and allocation era to assess effect modification. Of the 9383 candidates identified, those >176.5 cm had an increased likelihood of transplantation (subdistribution hazard ratio [sHR]: 1.15) compared to the 170 to 176.5 cm group, while those ≤162 cm had a lower likelihood (sHR: 0.70). The overall likelihood of transplantation was higher in the CAS era (sHR: 1.17). The interaction term for height ≤162 cm and CAS era was significant (sHR: 1.15), suggesting a modest improvement in access for this group under CAS. Further, candidates ≤162 cm experienced a higher hazard of mortality in the CAS era (HR: 1.60). These findings suggest that CAS modestly improves access for the shortest candidates, but refinements are needed to address ongoing inequities in this population.
身材矮小的肺移植候选人在等待名单上的时间比身材较高的候选人更长。新的综合分配评分(CAS)纳入了身高因素以提高分配公平性。我们评估了CAS对不同身高组等待名单结果的影响。我们查询了一个全国性移植数据库,以获取2021年至2024年登记的肺移植候选人信息,将其分为4个身高组:≤162厘米、162至170厘米、170至176.5厘米和>176.5厘米。竞争风险和Cox回归模型评估了身高对等待名单结果的影响,包括身高与分配时代之间的交互项以评估效应修正。在识别出的9383名候选人中,与身高在170至176.5厘米的组相比,身高>176.5厘米的候选人移植可能性增加(亚分布风险比[sHR]:1.15),而身高≤162厘米的候选人移植可能性较低(sHR:0.70)。在CAS时代,总体移植可能性更高(sHR:1.17)。身高≤162厘米与CAS时代的交互项具有显著性(sHR:1.15),表明在CAS下该组的准入情况有适度改善。此外,身高≤162厘米的候选人在CAS时代死亡风险更高(风险比[HR]:1.60)。这些发现表明,CAS适度改善了最矮候选人的准入情况,但仍需改进以解决该人群中持续存在的不公平问题。