Iacobelli Roberta, Tifi Priscilla, Perri Gianluigi, Ricci Zaccaria, Brancaccio Gianluca, Ragni Laura, d'Inzeo Victoria, Filippelli Sergio, Trezzi Matteo, Galletti Lorenzo
Pediatric Cardiology, Clinical Area of Fetal and Cardiovascular Sciences, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Pediatric Cardiac Surgery, Clinical Area of Fetal and Cardiovascular Sciences, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
World J Pediatr Congenit Heart Surg. 2025 Nov;16(6):790-800. doi: 10.1177/21501351251336234. Epub 2025 May 14.
BackgroundPulmonary valve-sparing repair (PVSR) of Tetralogy of Fallot (TOF) provides good results in selected patients. However, recurrent right ventricular outflow tract obstruction (RVOTO) can occur requiring surgical revision. We sought to evaluate the course of RVOTO after PVSR by serial echocardiographic (ECHO) assessment.MethodsA retrospective analysis was conducted in patients who underwent PVSR of TOF at our institution. Demographic, anatomical, surgical and 2D-ECHO data were collected. The cohort was divided into two groups: no reintervention group (group 1) and reintervention group (group 2).ResultsNinety-one patients were included in this study; 13 patients (14%) required reintervention. Right ventricular outflow tract ECHO peak gradient was significantly higher in group 2 at intraoperative transesophageal ECHO (iTEE) ( = .009), at hospital discharge ( = .021), at six months follow-up ( = .0001) and 12 to 36 months follow-up ( = .0001). A more prevalent subvalvular stenosis was found in group 2 at six months ( = .0011) and 12 to 36 months follow-up ( = .00069). An RVOT ECHO peak gradient of 30 mm Hg at iTEE ( = .025) and discharge ( = .011) was statistically associated with the need for reintervention.ConclusionsRight ventricular outflow tract peak gradient was significantly higher in group 2 than in group 1 at iTEE, discharge and follow-up, with an ECHO peak gradient of 30 mm Hg being predictive of reintervention At follow-up, residual RVOTO was prevalent at the subvalvular level in group 2. This information will be useful in clinical decision-making for TOF patients undergoing pulmonary valve sparing repair.
背景
法洛四联症(TOF)的保留肺动脉瓣修复术(PVSR)在特定患者中取得了良好效果。然而,可能会出现复发性右心室流出道梗阻(RVOTO),需要进行手术修正。我们试图通过连续超声心动图(ECHO)评估来评估PVSR术后RVOTO的病程。
方法
对在我们机构接受TOF的PVSR的患者进行回顾性分析。收集人口统计学、解剖学、手术和二维ECHO数据。该队列分为两组:无再次干预组(第1组)和再次干预组(第2组)。
结果
本研究纳入91例患者;13例患者(14%)需要再次干预。在术中经食管ECHO(iTEE)时(P = 0.009)、出院时(P = 0.021)、6个月随访时(P = 0.0001)以及12至36个月随访时(P = 0.0001),第2组的右心室流出道ECHO峰值梯度显著更高。在6个月时(P = 0.0011)以及12至36个月随访时(P = 0.00069),第2组发现更普遍的瓣下狭窄。iTEE时(P = 0.025)和出院时(P = 0.011)RVOT ECHO峰值梯度为30 mmHg与再次干预的需求在统计学上相关。
结论
在iTEE、出院时和随访时,第2组的右心室流出道峰值梯度显著高于第1组,ECHO峰值梯度为30 mmHg可预测再次干预。在随访时,第2组瓣下水平的残余RVOTO很普遍。这些信息将有助于接受保留肺动脉瓣修复术的TOF患者的临床决策。