Hadoush Hikmat, Hassoun Abdallah Al, Al-Wardat Mohammad, Almasri Nihad A, Etoom Mohammad
Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Department of Rehabilitation Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
NeuroRehabilitation. 2025 May 14:10538135251336924. doi: 10.1177/10538135251336924.
BackgroundStudies on non-invasive brain stimulation (NIBS) for children with cerebral palsy (CP) have yielded inconsistent findings regarding motor skills. This research will evaluate its efficacy through a systematic review.MethodA thorough search was conducted on the PubMed, Cochrane, and ScienceDirect databases, encompassing all trials that examined the impact of NIBS on balance, gait, and motor skills in children with CP. The analysis adhered to PRISMA guidelines.ResultsThe review included 17 trials, 13 assessing NIBS protocols, involving 385 children in the meta-analysis. Pooled analysis showed significant therapeutic effects on gait spatiotemporal outcomes in terms of walking speed (post-transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) multi-session treatment) and gait cadence (post-tDCS multi-session). In addition, tDCS multi-session showed significant therapeutic effects on standing abilities and mobility functions. However, no significant effect of tDCS on balance, step length, stride length, walking endurance, and GMFM-walking functions.ConclusionThis review highlighted the potential benefits of NIBS, particularly tDCS, in improving various motor functions in children with CP, such as walking speed, cadence, and mobility. However, its impact on balance and other gait factors remains inconclusive, indicating the need for further research to optimize NIBS protocols based on updated brain mapping findings.
背景
关于非侵入性脑刺激（NIBS）对脑瘫（CP）儿童运动技能影响的研究结果并不一致。本研究将通过系统评价来评估其疗效。
方法
对PubMed、Cochrane和ScienceDirect数据库进行了全面检索，纳入了所有考察NIBS对CP儿童平衡、步态和运动技能影响的试验。分析遵循PRISMA指南。
结果
该评价纳入了17项试验，其中13项评估NIBS方案，荟萃分析涉及385名儿童。汇总分析显示，在步行速度（经颅直流电刺激（tDCS）和重复经颅磁刺激（rTMS）多疗程治疗后）和步态节奏（tDCS多疗程治疗后）方面，对步态时空参数有显著治疗效果。此外，tDCS多疗程对站立能力和移动功能有显著治疗效果。然而，tDCS对平衡、步长、步幅、步行耐力和GMFM-步行功能无显著影响结论
本评价强调了NIBS，尤其是tDCS，在改善CP儿童多种运动功能（如步行速度、节奏和移动能力）方面的潜在益处。然而，其对平衡和其他步态因素的影响仍不明确，这表明需要进一步研究，以便根据最新的脑图谱研究结果优化NIBS方案。
