Luo X M, Wei H J, Yang C L, Xing J, Liu X, Qiao C H, Feng Y M, Liu J, Liu Y X, Wu Q
Am J Clin Nutr. 1985 Sep;42(3):439-48. doi: 10.1093/ajcn/42.3.439.
For 8 wk 5 groups of 10 men each were given 0.5 g/day DL-methionine, 150 micrograms Se/day as sodium selenite with or without methionine or 150 micrograms Se/day as selenomethionine with or without methionine. Twenty subjects received placebo as controls. Initially plasma Se rose more rapidly than RBC Se. Increases in Se levels were significantly greater with selenomethionine than with the selenite supplement. In the placebo and methionine supplemented groups neither plasma nor RBC Se varied significantly over the course of the study. Supplementation with selenium resulted in marked increases in plasma and RBC GSH-Px within 2 and 4 wk, respectively. Plasma and RBC GSH-Px activity did not differ significantly between Se-supplemented groups. These studies suggest that selenomethionine-Se was more effective in raising plasma and RBC Se than was selenite-Se. Methionine supplements may increase the bioavailability of selenium in severely deficient subjects.
8周内，将5组每组10名男性，分别给予每日0.5克DL-蛋氨酸、每日150微克亚硒酸钠（含或不含蛋氨酸）或每日150微克硒代蛋氨酸（含或不含蛋氨酸）。20名受试者接受安慰剂作为对照。最初，血浆硒比红细胞硒上升得更快。硒代蛋氨酸组的硒水平升高显著高于亚硒酸盐补充组。在安慰剂组和补充蛋氨酸的组中，整个研究过程中血浆和红细胞硒均无显著变化。补充硒分别在2周和4周内导致血浆和红细胞谷胱甘肽过氧化物酶（GSH-Px）显著增加。补充硒的组之间血浆和红细胞GSH-Px活性无显著差异。这些研究表明，硒代蛋氨酸硒在提高血浆和红细胞硒方面比亚硒酸钠硒更有效。补充蛋氨酸可能会增加严重缺乏硒的受试者对硒的生物利用度。
