Deng Z L, Connor D H
Am J Clin Pathol. 1985 Sep;84(3):323-7. doi: 10.1093/ajcp/84.3.323.
Eight patients with fatal penicilliosis caused by Penicillium marneffei are reported. All were natives of southern rural Guangxi, and none had a predisposing illness or evidence of altered immunity. The distinctive features of P. marneffei include proliferation of yeast-like cells within histiocytes, followed by the development of focal necrosis and, eventually, large abscesses. Outside the histiocytes, the fungi elongate, become slightly curved, and form septa. In vitro, P. marneffei produces a red pigment which diffuses into the culture medium. The differentiation between P. marneffei and Histoplasma capsulatum is described, and possible reservoirs for P. marneffei are discussed.
本文报告了8例由马尔尼菲青霉菌引起的致死性马尔尼菲青霉病患者。所有患者均来自广西南部农村，均无基础疾病或免疫功能改变的证据。马尔尼菲青霉菌的显著特征包括组织细胞内酵母样细胞的增殖，随后出现局灶性坏死，最终形成大脓肿。在组织细胞外，真菌伸长，略微弯曲并形成隔膜。在体外，马尔尼菲青霉菌产生一种扩散到培养基中的红色色素。文中描述了马尔尼菲青霉菌与荚膜组织胞浆菌的鉴别，并讨论了马尔尼菲青霉菌可能的储存宿主。
