Jayanetra P, Nitiyanant P, Ajello L, Padhye A A, Lolekha S, Atichartakarn V, Vathesatogit P, Sathaphatayavongs B, Prajaktam R
Am J Trop Med Hyg. 1984 Jul;33(4):637-44. doi: 10.4269/ajtmh.1984.33.637.
The first two cases of Penicillium marneffei infection in humans were reported in 1959 and 1973. There had been no additional clinical reports of penicilliosis marneffei, until the five new cases of human infection described in this paper, the first from Thailand. The patients, three of whom died, came from various parts of the country. Their common clinical manifestations were fever and generalized lymphadenopathy, with multiple soft tissue, bone, joint and pulmonary involvement. Pericarditis with effusion was also seen. The diagnosis was established by isolating and identifying a dimorphic Penicillium species that produced a soluble red pigment in its mycelial form. The histopathologic features of the lymph nodes and bone marrow were similar to those of histoplasmosis capsulati. However, the yeast-like tissue form of P. marneffei divides by fission; that of Histoplasma capsulatum by budding. Treatment with amphotericin B was effective when this antifungal antibiotic was administered early in the course of the disease.
1959年和1973年分别报道了首例人类马尔尼菲青霉感染病例。在本文描述的5例新的人类感染病例（首例来自泰国）之前，没有马尔尼菲青霉病的其他临床报告。这些患者来自该国不同地区，其中3例死亡。他们的常见临床表现为发热和全身淋巴结肿大，伴有多部位软组织、骨骼、关节和肺部受累。还发现了伴有积液的心包炎。通过分离和鉴定一种在菌丝体形式下产生可溶性红色色素的双相青霉属菌种来确诊。淋巴结和骨髓的组织病理学特征与荚膜组织胞浆菌病相似。然而，马尔尼菲青霉的酵母样组织形式通过裂殖进行分裂；荚膜组织胞浆菌则通过出芽进行分裂。在疾病早期使用两性霉素B治疗有效。
