Gao Ya, Li Wenbo, Li Zhongxing, Wu Fenglian, Wang Jiaxin
Department of Graduate School, Hebei North University, Qiaoxi District, Zhangjiakou City, 075000, Hebei Province, China.
Department of Plastic and Cosmetic Surgery, Department of Surgery, First Hospital of Qinhuangdao, No. 258, Wenhua Road, Haigang District, Qinhuangdao City, 066000, Hebei Province, China.
Aesthetic Plast Surg. 2025 May 14. doi: 10.1007/s00266-025-04886-w.
There are many treatments for keloid. In recent years, botulinum toxin type A(BTX-A)has been proposed to treat keloid. The purpose of our study was to observe the clinical effect of BTX-A combined with superficial radiotherapy after chest keloid surgery.
60 patients with medium and large chest keloid treated from October 2021 to October 2023 were selected and randomly divided into group A and group B, with 30 cases in each group. Keloid resection was performed in both groups first, group A was treated with BTX-A combined with superficial radiotherapy, group B only received early superficial radiotherapy after surgery, and the therapeutic effect of the two groups was compared.
After 6 months follow-up observation, the total effective rate and satisfaction of group A were higher than those of group B, and the Vancouver scar scale(VSS) score of group A was lower than that of group B, the difference was statistically significant (P < 0.05).
We concluded that immediate injection of BTX-A combined with superficial radiotherapy after chest keloid surgery was superior to simple superficial radiotherapy after surgery, with higher patient satisfaction and lower recurrence rate, which was worthy of clinical application.
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瘢痕疙瘩有多种治疗方法。近年来，A型肉毒杆菌毒素（BTX-A）被提议用于治疗瘢痕疙瘩。本研究的目的是观察BTX-A联合浅表放疗在胸部瘢痕疙瘩手术后的临床效果。
选取2021年10月至2023年10月治疗的60例中大型胸部瘢痕疙瘩患者，随机分为A组和B组，每组30例。两组均先行瘢痕疙瘩切除术，A组采用BTX-A联合浅表放疗，B组仅在术后早期接受浅表放疗，比较两组的治疗效果。
经过6个月的随访观察，A组的总有效率和满意度高于B组，A组的温哥华瘢痕量表（VSS）评分低于B组，差异有统计学意义（P<0.05）。
我们得出结论，胸部瘢痕疙瘩手术后立即注射BTX-A联合浅表放疗优于单纯术后浅表放疗，患者满意度更高，复发率更低，值得临床应用。
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