Portilla-Tamarit Julia, Fuster-RuizdeApodaca María José, Portilla-Tamarit Irene, Reus Sergio, Riera Melchor, Espinosa Nuria, Martín Juan, Bernal Enrique, Masia Mar, Calzado Sonia, Portilla Joaquín
Infectious Diseases Unit and Internal Medicine Department, University General Hospital Dr, Balmis, Alicante, Spain.
Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.
AIDS Behav. 2025 May 15. doi: 10.1007/s10461-025-04730-x.
Our aim was to evaluate long-term health-related quality of life (HRQoL) in 253 people living with HIV (PLH) from the CoRIS cohort presenting to care with advanced HIV disease (AIDS or CD4 ≤ 100 cells/µL) and who had survived ≥ 5 years. Participants completed the WHOQOL-HIV-BREF and EQ-5D-5 L questionnaires. Clinical and immunological data were provided by the CoRIS at enrollment and on questionnaire completion. Linear repeated measures analyses assessed the evolution of immunological markers. Partial least squares structural equation modeling showed the longitudinal impact of baseline immunological markers on HRQoL. High baseline CD4 counts predicted higher WHOQOL-HIV-BREF independence scores (p = 0.021) and a marginally higher EQ-5D-5 L index value (p = 0.058), which was also associated with CD8 (p = 0.015). A higher CD4/CD8 ratio predicted lower scores on the WHOQOL-HIV-BREF 'spirituality, religion and personal belief' dimension (p = 0.006). Currently, PLH who present with advanced HIV disease achieve a moderate long-term HRQoL, with room for improvement.
我们的目标是评估来自CoRIS队列的253名艾滋病病毒感染者（PLH）的长期健康相关生活质量（HRQoL），这些感染者患有晚期艾滋病病毒疾病（艾滋病或CD4≤100个细胞/µL）且存活时间≥5年。参与者完成了世界卫生组织生活质量HIV简表（WHOQOL-HIV-BREF）和欧洲五维度健康量表（EQ-5D-5L）问卷。CoRIS在入组时和问卷完成时提供了临床和免疫数据。线性重复测量分析评估了免疫标志物的演变。偏最小二乘结构方程模型显示了基线免疫标志物对HRQoL的纵向影响。基线CD4细胞计数高预示着世界卫生组织生活质量HIV简表的独立得分更高（p = 0.021），欧洲五维度健康量表指数值略高（p = 0.058），这也与CD8相关（p = 0.015）。较高的CD4/CD8比值预示着世界卫生组织生活质量HIV简表“精神、宗教和个人信仰”维度的得分较低（p = 0.006）。目前，患有晚期艾滋病病毒疾病的PLH实现了中等程度的长期HRQoL，但仍有改善空间。
