Abd El-Raheem Ghada Omer Hamad, Dihesh Mohamed Elhadi Ahmed, Elmardi Mohamed Elmutaz Babikir, Elamin Hana Eltayeb Salih, Zeinelabdin Latifa Elsir Abas, Ahmed Dalia Omer Suliman, Mudather Misa Abdelmajid Alhaj, Gaber Omema Abdelkrem Abdelftah, Abdalla Hanadie Mustafa Ebrahim
Soba University Hospital, Sudan Police Head Quarters- Hospitals and Treatment Centers, Intensive Care Units, Khartoum, 11114, Sudan.
Intensive care unit, Sudan Police Head Quarters- Hospitals and Treatment Centers, Intensive Care Units, Khartoum, 11114, Sudan.
BMC Microbiol. 2025 May 14;25(1):290. doi: 10.1186/s12866-025-04021-4.
Antibiograms are statistics on bacterial spectrum and resistance rates. It is of importance to regularly monitor the trends in antimicrobial resistance within the institution through the periodic cumulative resistance to provide the effective empiric antibiotic selection, enhanced infection control interventions, and containment strategies. Antimicrobial stewardship interventions improve quality and quantity of prescribing antimicrobial in ICUs without compromising any patient outcomes. The aim of this study was to develop a local unit-specific antibiogram for the Intensive Care Units based on the susceptibility rates of antimicrobials. Facility- based cross sectional study was done among ICU patients of a Tertiary hospital, Khartoum. Data were collected from the record of microbiology Laboratory from August-2021 to September-2022. Results were presented as tables and figures, Chi- square test was used to assess associations between variables, results were statistically significant when p < 0.05. Gram negative bacteria comprised 32% of the samples and only 4% of the samples had Gram positive bacteria, the remaining samples had no growth. Klebsiella spp. were the most prevalent 14.4% (44/306). The lowest susceptibility to antimicrobials were documented for Acinetobacter spp. and Klebsiella spp. Regarding Pseudomonas aeruginosa, it was susceptible to Meropenem but resistant to Pip/Tazo and Aminoglycosides. Gram positive bacteria, all were susceptible to Vancomycin and low Methicillin-resistant Staphylococcus aureus prevalence was observed. The antibiogram revealed high prevalence of Gram negative bacteria with low antimicrobials-susceptibility; especially Klebsiella spp. Low prevalence was recorded for MRSA and the most prevalent Gram positive bacteria were E. faecalis. This antibiogram of ICU can provide a reference for all future ICU antibiograms which will give a clear picture of the antimicrobial susceptibility pattern among ICU patients. Clinical trial number Not applicable.
抗菌谱是关于细菌谱和耐药率的统计数据。通过定期累积耐药性来定期监测机构内抗菌药物耐药性的趋势，对于提供有效的经验性抗生素选择、加强感染控制干预措施和遏制策略至关重要。抗菌药物管理干预措施可提高重症监护病房（ICU）抗菌药物处方的质量和数量，且不影响任何患者的治疗结果。本研究的目的是根据抗菌药物的药敏率，为重症监护病房制定一个针对当地科室的抗菌谱。在喀土穆一家三级医院的ICU患者中进行了基于机构的横断面研究。数据收集于2021年8月至2022年9月的微生物实验室记录。结果以表格和图表形式呈现，采用卡方检验评估变量之间的关联，当p<0.05时结果具有统计学意义。革兰氏阴性菌占样本的32%，只有4%的样本含有革兰氏阳性菌，其余样本无生长。克雷伯菌属最为常见，占14.4%（44/306）。不动杆菌属和克雷伯菌属对抗菌药物的敏感性最低。对于铜绿假单胞菌，它对美罗培南敏感，但对哌拉西林/他唑巴坦和氨基糖苷类耐药。革兰氏阳性菌均对万古霉素敏感，且耐甲氧西林金黄色葡萄球菌的患病率较低。抗菌谱显示革兰氏阴性菌患病率高且对抗菌药物敏感性低；尤其是克雷伯菌属。耐甲氧西林金黄色葡萄球菌的患病率较低，最常见的革兰氏阳性菌是粪肠球菌。该ICU抗菌谱可为未来所有ICU抗菌谱提供参考，从而清晰呈现ICU患者的抗菌药物敏感性模式。临床试验编号：不适用。
