Sainz R, Lanas A, Martinez T, Montoro M, Bueno J
Am J Gastroenterol. 1985 Sep;80(9):673-7.
The effect of duodenal acidification on pentagastrin-stimulated gastric acid secretion was studied in 43 duodenal ulcer patients and in 17 normal controls. Three types of responses were observed: group A, no inhibition of gastric acid secretion occurred in 17 (40%) ulcer patients and in three (18%) controls (p less than 0.05); group B, inhibition of gastric acidity occurred in seven (16%) ulcer patients and in 12 (71%) controls (p less than 0.05), and group C, retarded gastric acid inhibition occurred in 19 (44%) duodenal ulcer patients and in 2 (12%) controls (p less than 0.05). Secretin levels did not increase after duodenal acidification, the higher percentages of failure being observed in groups A and C (p less than 0.05). The pH of the duodenal aspirate was 4.9 +/- 2 and 7.7 +/- 1.4 in ulcer patients and controls, respectively (p less than 0.05), with the low levels being detected in groups A and C (4.7 +/- 2 and 5.3 +/- 2.1) compared to group B (7.3 +/- 1.7; p less than 0.05). The results show that responses of duodenal ulcer patients to duodenal acidification are heterogeneous, and that failure of gastric secretion inhibition and defective intraduodenal acid neutralization are related.
在43例十二指肠溃疡患者和17例正常对照者中研究了十二指肠酸化对五肽胃泌素刺激胃酸分泌的影响。观察到三种类型的反应：A组，17例（40%）溃疡患者和3例（18%）对照者胃酸分泌未受抑制（p<0.05）；B组，7例（16%）溃疡患者和12例（71%）对照者胃酸分泌受到抑制（p<0.05）；C组，19例（44%）十二指肠溃疡患者和2例（12%）对照者胃酸抑制延迟（p<0.05）。十二指肠酸化后促胰液素水平未升高，A组和C组观察到较高的失败率（p<0.05）。十二指肠抽吸物的pH值在溃疡患者和对照者中分别为4.9±2和7.7±1.4（p<0.05），与B组（7.3±1.7；p<0.05）相比，A组和C组检测到较低水平（4.7±2和5.3±2.1）。结果表明，十二指肠溃疡患者对十二指肠酸化的反应是异质性的，胃酸分泌抑制失败和十二指肠内酸中和缺陷是相关的。
