The relationship between stigma and psychological distress among Chinese youth with epilepsy: the mediating role of physical activity.

BACKGROUND

Youth with epilepsy suffer from stigma, which is closely associated with increased levels of psychological distress, particularly anxiety and depression. Studies have found that the stigma associated with epilepsy is strongly linked to reduced levels of physical activity (PA). However, the combined contribution of stigma and PA to psychological distress remains unclear.

AIM

This study aims to investigate the mediating role of PA to determine whether PA mediates the relationship between stigma and psychological distress among youth with epilepsy.

METHODS

We conducted a multicentre cross-sectional survey involving youth with epilepsy in nine tertiary hospitals across China from October 2023 to March 2024. The study enrolled 226 youth with epilepsy between the ages of 8 and 18. The dependent variable was psychological distress, assessed using the Depression Anxiety and Stress Scale (DASS-21). Data collection involved the administration of a comprehensive questionnaire that included the DASS-21, the Kilifi Stigma Scale for Epilepsy (KSSE) to assess stigma, and the Physical Activity Rating Scale (PARS-3) to assess PA.

RESULTS

Psychological distress increased significantly with increasing levels of stigma, whereas a decrease was observed with increasing levels of PA (p < 0.01). The results showed PA mainly plays partial mediating roles in the relationship between stigma and depression (ab = 0.042, 95% CI: 0.016 to 0.068), anxiety (ab = 0.077, 95% CI: 0.054 to 0.099) and stress (ab = 0.092, 95% CI: 0.061 to 0.122) dimensions of psychological distress. Additionally, intensity and frequency respectively only intermediated the relationship between stigma and anxiety and stress; duration all mediated between stigma and the psychological distress dimensions.

CONCLUSIONS

Stigma could increase psychological distress by indirectly influencing PA and its components. Interventions to improve physical activity may prevent or reduce psychological distress among youth with epilepsy.