Ganapathy M E, Mahesh V B, Devoe L D, Leibach F H, Ganapathy V
Am J Obstet Gynecol. 1985 Sep 1;153(1):83-6. doi: 10.1016/0002-9378(85)90600-3.
We studied the transport of glycylsarcosine by the brush-border membrane vesicles isolated from normal term human placentas. This dipeptide resisted hydrolysis by placental membrane vesicles and was transported intact into an osmotically responsive intravesicular space. The transport process was Na+-independent and probably occurred down a concentration gradient. Many peptides inhibited the transport of glycylsarcosine whereas amino acids had no effect. These results demonstrate, for the first time, the presence of a dipeptide transport system in the human placenta.
我们研究了从足月正常人类胎盘分离出的刷状缘膜囊泡对甘氨酰肌氨酸的转运。这种二肽能抵抗胎盘膜囊泡的水解作用，并完整地转运至对渗透压有反应的囊泡内空间。转运过程不依赖钠离子，可能是顺着浓度梯度进行的。许多肽类抑制甘氨酰肌氨酸的转运，而氨基酸则无此作用。这些结果首次证明了人类胎盘中存在二肽转运系统。
