Endoplasmic reticulum stress in non-small cell lung cancer.

The Endoplasmic reticulum (ER), an organelle present in various eukaryotic cells, is responsible for protein synthesis, modification, folding, and transport, as well as for the regulation of lipid metabolism and Ca homeostasis. ER stress plays a pivotal role in the pathogenesis and therapeutic response of non-small cell lung cancer (NSCLC), significantly influencing cellular fate decisions through its unique sensing and regulatory mechanisms. This review aims to elucidate the key role of ER stress sensors and to explore how they mediate cell autophagy, apoptosis, and non-apoptotic modes of cell death in the context of drug-treated NSCLC. This investigation lays a solid foundation for optimizing future treatment strategies for NSCLC.