老年慢性病患者非正式照护者的健康状态效用值及其恶化时间。

Health-state utility values and their time to deterioration in informal caregivers of older patients with chronic diseases.

作者信息

Pozet Astrid, Falcoz Antoine, Roller Cécile, Jai Taha, Meurisse Aurelia, Nerich Virginie

机构信息

CHU de Besançon, Délégation à la Recherche Clinique et à l'Innovation, Besançon, France.

CHU de Besançon, INSERM, EFS-BFC, UMR 1098, Methodological and Quality of Life in Oncology Unit, Besançon, France.

出版信息

Front Public Health. 2025 Apr 30;13:1531608. doi: 10.3389/fpubh.2025.1531608. eCollection 2025.

DOI:10.3389/fpubh.2025.1531608

PMID:40371298

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12074913/

Abstract

OBJECTIVES

This study aimed to assess health state utility values (HSUVs) in caregivers of older patients with chronic diseases receiving or not receiving social worker support.

METHODS

This multicentric open-label randomized study assigned caregivers to receive either an informational booklet alone or one accompanied by social worker support. Caregivers completed EQ-5D-3L each semester for 24 months. We reported caregiver HSUVs at baseline and after 6, 12, 18, and 24 months using EQ-5D-3L utility index scores and exploring their time to deterioration (TTD).

RESULTS

Among 179 included caregivers, the percentage reporting some or extreme problems on five EQ-5D-3L dimensions remained almost stable over time with a median EQ-5D-3L utility index score of 0.89 [0.80-1.00] at baseline ( = 177), 0.80 [0.80-0.89] at M6 ( = 125), and 0.80 [0.73-0.91] at M24 ( = 81). Among the respondents, 62% ( = 109) experienced a deterioration in EQ-5D-3L utility index score, with a median TTD of 9.1 months [95%CI 6.2-14.9] in the control group (CG) and 9.5 months [6.3-14.4] in the supportive intervention group (SIG) (HR = 1.06 [0.73-1.54]), -value = 0.76.

CONCLUSION

Our study provides a catalog of HSUVs across different caregiver profiles and at various follow-up time points, which can inform future economic evaluations.

CLINICAL TRIAL REGISTRATION

ClinicalTrials.gov, NCT02626377.

摘要

目的

本研究旨在评估接受或未接受社会工作者支持的老年慢性病患者照料者的健康状态效用值（HSUVs）。

方法

这项多中心开放标签随机研究将照料者分为两组，一组仅接收一本信息手册，另一组则在接收信息手册的同时获得社会工作者的支持。照料者在24个月内每学期完成一次EQ-5D-3L问卷调查。我们使用EQ-5D-3L效用指数得分报告了照料者在基线以及6、12、18和24个月后的HSUVs，并探究了他们的恶化时间（TTD）。

结果

在179名纳入研究的照料者中，在EQ-5D-3L的五个维度上报告有一些或极端问题的比例随时间推移基本保持稳定，基线时EQ-5D-3L效用指数得分的中位数为0.89[0.80 - 1.00]（n = 177），6个月时为0.80[0.80 - 0.89]（n = 125），24个月时为0.80[0.73 - 0.91]（n = 81）。在受访者中，62%（n = 109）的EQ-5D-3L效用指数得分出现恶化，对照组（CG）的恶化时间中位数为9.1个月[95%CI 6.2 - 14.9]，支持性干预组（SIG）为9.5个月[6.3 - 14.4]（HR = 1.06[0.73 - 1.54]），P值 = 0.76。