阑尾切除术在炎症性肠病中的地位——综述
The Place of Appendicectomy in Inflammatory Bowel Disease-A Review.
作者信息
Naidu Krishanth, Wong Pearl, Chapuis Pierre H, Rickard Matthew J F X, Ng Kheng-Seong
机构信息
Colorectal Surgery Unit, Concord Hospital, Concord, Australia.
Concord Institute of Academic Surgery, Concord Hospital, Concord, Australia.
出版信息
ANZ J Surg. 2025 Jun;95(6):1091-1095. doi: 10.1111/ans.70157. Epub 2025 May 15.
The aetiology and pathophysiology of inflammatory bowel disease (IBD) are not completely understood; however, a dysregulated intestinal immune system appears key to its pathogenesis. It has been suggested that the appendix is central to nurturing the enteric mucosal system due to its production of lymphoid products and that an appendicectomy may have an immune modulating effect. The aim of this review is to explore the available evidence for the association between IBD and appendicectomy and attempt to define its impact on the incidence and risk of Crohn's disease (CD) and Ulcerative colitis (UC) onset and progression.
炎症性肠病（IBD）的病因和病理生理学尚未完全明确；然而，肠道免疫系统失调似乎是其发病机制的关键。有人认为，阑尾因其产生淋巴样产物而对滋养肠道黏膜系统至关重要，阑尾切除术可能具有免疫调节作用。本综述的目的是探讨IBD与阑尾切除术之间关联的现有证据，并试图确定其对克罗恩病（CD）和溃疡性结肠炎（UC）发病及进展的发生率和风险的影响。
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