硬膜外注射美普他酚用于下腹部手术后的疼痛缓解。

Epidural meptazinol for pain relief after lower abdominal surgery.

作者信息

Rao U, Campbell I T, Catley D M, Sutherst J R

出版信息

Anaesthesia. 1985 Aug;40(8):754-8. doi: 10.1111/j.1365-2044.1985.tb10999.x.

DOI:10.1111/j.1365-2044.1985.tb10999.x

Abstract

A preliminary investigation is reported into the use of epidural meptazinol for pain relief in 20 patients after major lower abdominal (gynaecological) surgery. Analgesia was rapid in onset (15 minutes), had a median duration of 124 minutes (interquartile range 85-212 minutes) after a single dose of 30 mg and a median duration of 122.5 minutes (interquartile range 70-127 minutes) after a single dose of 60 mg. Overall pain relief, as judged by the patients themselves, was satisfactory in 19 out of the 20 cases. At 30 minutes and 45 minutes pain relief was significantly better with the 60 mg than the 30 mg dose (p less than 0.02). No drug-related adverse effects were observed during the study.

摘要

报告了一项关于硬膜外注射美普他酚用于 20 例下腹部（妇科）大手术后疼痛缓解的初步研究。镇痛起效迅速（15 分钟），单次注射 30 mg 后中位持续时间为 124 分钟（四分位间距 85 - 212 分钟），单次注射 60 mg 后中位持续时间为 122.5 分钟（四分位间距 70 - 127 分钟）。根据患者自身判断，20 例中有 19 例总体疼痛缓解情况令人满意。在 30 分钟和 45 分钟时，60 mg 剂量组的疼痛缓解明显优于 30 mg 剂量组（p < 0.02）。研究期间未观察到与药物相关的不良反应。