Boyle Lara M, Sheng Wanhui, Villegas Andres, Sahai Rhea, Irfan Sarah, Lee Heon-Jin, Young W Scott, Leroy Felix, Siegelbaum Steven A
Department of Neuroscience, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Cell Rep. 2025 May 27;44(5):115714. doi: 10.1016/j.celrep.2025.115714. Epub 2025 May 13.
The dorsal and ventral regions of the CA1 field of the hippocampus play distinct roles in the encoding of cognitive vs. emotional behaviors, respectively. Whether this distinction applies to other hippocampal fields and other behaviors is unclear. Here, we focus on the hippocampal CA2 field and compare the properties and behavioral roles of its dorsal (dCA2) and ventral (vCA2) regions. Although dCA2 is known to be required for social memory and to promote social aggression, the role of vCA2 is unknown. We report that a defined CA2 region extends to the extreme ventral pole of the hippocampus, with certain distinctions to dCA2. Unlike dCA2, chemogenetic silencing of vCA2 pyramidal neurons did not impair social memory. Similar to dCA2, vCA2 was required to promote social aggression. Thus, consistent with the CA1 region, CA2 may be differentially tuned to support cognitive compared with emotional processes along its dorsal to ventral axis.
海马体CA1区的背侧和腹侧区域分别在认知行为和情感行为的编码中发挥着不同的作用。这种差异是否适用于其他海马体区域和其他行为尚不清楚。在这里，我们聚焦于海马体CA2区，比较其背侧（dCA2）和腹侧（vCA2）区域的特性和行为作用。尽管已知dCA2对社交记忆是必需的，并能促进社会攻击行为，但vCA2的作用尚不清楚。我们报告称，一个特定的CA2区域延伸至海马体的极端腹侧极，与dCA2存在某些差异。与dCA2不同，vCA2锥体神经元的化学遗传学沉默并未损害社交记忆。与dCA2相似，vCA2是促进社会攻击行为所必需的。因此，与CA1区一致，CA2区可能沿着其背腹轴被差异调节，以支持认知过程而非情感过程。
