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[肺移植的适应证——自国际心肺移植学会上次建议以来的更新]

[Indications for Lung Transplantation - Updates Since the Last ISHLT Recommendations].

作者信息

Kovacs Zsofia, Benazzo Alberto, Jaksch Peter

机构信息

Thoraxchirurgie, Medizinische Universität Wien, Wien, Österreich.

出版信息

Zentralbl Chir. 2025 Jun;150(3):256-260. doi: 10.1055/a-2563-3691. Epub 2025 May 15.

Abstract

Lung transplantation has evolved continuously since its first successful procedures in the 1960 s. The current guidelines from the International Society for Heart and Lung Transplantation (ISHLT) emphasise increasingly individualised patient assessment, which, in addition to the underlying lung disease, considers factors such as comorbidities, frailty, age, and social aspects. The expanded indications for lung transplantation are reflected in the refined risk assessment, which particularly includes patients with advanced chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary arterial hypertension (PAH). Furthermore, the criteria for patients with a history of cancer and those with infections such as HIV or multidrug-resistant organisms have been made more flexible, leading to a more inclusive transplantation policy. A key focus is on early transplant counselling, allowing patients the opportunity for transplantation before they develop acute exacerbations. These updated guidelines aim to maximise both the survival rates and the quality of life of transplant patients, through differentiated and risk-adjusted decision-making.

摘要

自20世纪60年代首次成功进行肺移植手术以来,肺移植技术一直在不断发展。国际心肺移植学会(ISHLT)目前的指南强调越来越个体化的患者评估,除了潜在的肺部疾病外,还会考虑合并症、身体虚弱、年龄和社会因素等。肺移植适应证的扩大体现在细化的风险评估中,特别包括晚期慢性阻塞性肺疾病(COPD)、特发性肺纤维化(IPF)和肺动脉高压(PAH)患者。此外,有癌症病史的患者以及感染艾滋病毒或多重耐药菌等感染的患者的标准也更加灵活,从而形成了更具包容性的移植政策。一个关键重点是早期移植咨询,让患者有机会在发生急性加重之前接受移植。这些更新后的指南旨在通过差异化和风险调整后的决策,最大限度地提高移植患者的生存率和生活质量。

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