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第八届药物研究中的磷脂国际研讨会——海德堡磷脂研究中心两年一度的研讨会上展示的磷脂当前研究最新情况

The 8th International Symposium on Phospholipids in Pharmaceutical Research - An update on current research in phospholipids presented at the biennial symposium of the Phospholipid Research Center Heidelberg.

作者信息

Drescher Simon, Blume Alfred

机构信息

Phospholipid Research Center, Im Neuenheimer Feld 515 D-69120, Heidelberg, Germany.

Phospholipid Research Center, Im Neuenheimer Feld 515 D-69120, Heidelberg, Germany; Martin-Luther-University Halle-Wittenberg, Institute of Chemistry - Physical Chemistry, von-Danckelmann-Platz 4 D-06120, Halle (Saale), Germany.

出版信息

Eur J Pharm Sci. 2025 Jul 1;210:107126. doi: 10.1016/j.ejps.2025.107126. Epub 2025 May 13.

DOI:10.1016/j.ejps.2025.107126
PMID:40374026
Abstract

This Conference Report recaps recent advances in the research on phospholipids and their applications for advanced drug delivery and analytical purposes that have been presented at the "8th International Symposium on Phospholipids in Pharmaceutical Research" of the Phospholipid Research Center (PRC), held from September 09-11, 2024, at the University of Heidelberg, Germany. The PRC is a non-profit organization focused on expanding and sharing scientific and technological knowledge of phospholipids in pharmaceutical and related applications. This is accomplished by, e.g., funding doctoral and postdoctoral research projects at universities worldwide. The PRC organizes this symposium every two years, at which international experts from science and industry present innovative and new applications of phospholipids. This year's symposium highlighted advancements in lipid-based gene and RNA delivery, anisotropic lipid nanoparticles, PEGylation challenges, tetraether lipids for drug delivery, ethical considerations in publishing, multifunctional lipopeptides, and phospholipid applications in therapeutics. Discussions also showcased award-winning research on optimizing liposome drug compatibility, reflecting the expanding role of phospholipids in pharmaceutical science.

摘要

本会议报告概述了磷脂及其在先进药物递送和分析目的方面应用的最新研究进展,这些进展在2024年9月9日至11日于德国海德堡大学举行的磷脂研究中心(PRC)“第8届药物研究中的磷脂国际研讨会”上有所展示。PRC是一个非营利组织,专注于扩展和分享磷脂在制药及相关应用方面的科技知识。这通过例如资助全球各大学的博士和博士后研究项目来实现。PRC每两年组织一次该研讨会,来自科学界和工业界的国际专家会在会上展示磷脂的创新和新应用。今年的研讨会重点介绍了基于脂质的基因和RNA递送、各向异性脂质纳米颗粒、聚乙二醇化挑战、用于药物递送的四醚脂质、出版中的伦理考量、多功能脂肽以及磷脂在治疗学中的应用等方面的进展。讨论还展示了关于优化脂质体药物相容性的获奖研究,这反映了磷脂在药学领域日益扩大的作用。

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