Drescher Simon, van Hoogevest Peter
Phospholipid Research Center, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany.
Pharmaceutics. 2020 Dec 18;12(12):1235. doi: 10.3390/pharmaceutics12121235.
This review summarizes the research on phospholipids and their use for drug delivery related to the Phospholipid Research Center Heidelberg (PRC). The focus is on projects that have been approved by the PRC since 2017 and are currently still ongoing or have recently been completed. The different projects cover all facets of phospholipid research, from basic to applied research, including the use of phospholipids in different administration forms such as liposomes, mixed micelles, emulsions, and extrudates, up to industrial application-oriented research. These projects also include all routes of administration, namely parenteral, oral, and topical. With this review we would like to highlight possible future research directions, including a short introduction into the world of phospholipids.
本综述总结了与海德堡磷脂研究中心(PRC)相关的磷脂及其在药物递送方面应用的研究。重点关注自2017年以来已获PRC批准、目前仍在进行或最近已完成的项目。不同的项目涵盖了磷脂研究的各个方面,从基础研究到应用研究,包括磷脂在不同给药形式(如脂质体、混合胶束、乳剂和挤出物)中的应用,直至面向工业应用的研究。这些项目还包括所有给药途径,即肠胃外、口服和局部给药。通过本综述,我们希望突出未来可能的研究方向,包括对磷脂世界的简要介绍。