• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Letter: Suggestions for Improving Study Design and Incorporating Virological Markers in HBV Functional Cure Research.信件:关于改进研究设计及在乙肝功能性治愈研究中纳入病毒学标志物的建议
Clin Transl Gastroenterol. 2025 May 16;16(8):e00847. doi: 10.14309/ctg.0000000000000847. eCollection 2025 Aug 1.
2
Functional cure with new antiviral therapy for hepatitis B virus: a systematic review and meta-analysis.新型抗乙肝病毒疗法的功能性治愈:一项系统评价与荟萃分析
Hepatol Int. 2025 Jun 18. doi: 10.1007/s12072-025-10823-5.
3
Functional cure in a child with chronic hepatitis B with rtM204I mutation through an atypical serological response: a case report.通过非典型血清学反应实现rtM204I突变慢性乙型肝炎患儿的功能性治愈:一例报告
Transl Pediatr. 2025 Jul 31;14(7):1726-1732. doi: 10.21037/tp-2025-250. Epub 2025 Jul 25.
4
Guidance on treatment endpoints and study design for clinical trials aiming to achieve cure in chronic hepatitis B and D: Report from the 2022 AASLD-EASL HBV-HDV Treatment Endpoints Conference.旨在实现慢性乙型肝炎和丁型肝炎治愈的临床试验治疗终点和研究设计指南:2022 年美国肝病研究学会-欧洲肝脏研究学会乙型肝炎-丁型肝炎治疗终点会议报告。
J Hepatol. 2023 Nov;79(5):1254-1269. doi: 10.1016/j.jhep.2023.06.002. Epub 2023 Jun 21.
5
HBV serum RNA kinetics during nucleic acid polymers based therapy predict functional cure.基于核酸聚合物治疗期间的HBV血清RNA动力学可预测功能性治愈。
Antiviral Res. 2025 Feb;234:106061. doi: 10.1016/j.antiviral.2024.106061. Epub 2024 Dec 19.
6
Serum hepatitis B virus RNA in low-level viremia of chronic hepatitis B: clinical features and association with virological response.慢性乙型肝炎低水平病毒血症中的血清乙型肝炎病毒RNA:临床特征及其与病毒学应答的关联
Virol J. 2025 May 5;22(1):132. doi: 10.1186/s12985-025-02712-y.
7
Recurrence risk factors for chronic hepatitis B virus-infected patients who achieve functional cure with pegylated interferon-α-2b-based therapy: a multicenter pilot study.基于聚乙二醇化干扰素-α-2b治疗实现功能性治愈的慢性乙型肝炎病毒感染患者的复发风险因素:一项多中心试点研究。
Virol J. 2025 May 19;22(1):146. doi: 10.1186/s12985-025-02761-3.
8
Hepatitis B Virus RNA as a Biomarker for Safe Antiviral Discontinuation: A Prospective Study of Nucleos(t)ide Analogue Withdrawal.乙型肝炎病毒RNA作为安全停用抗病毒药物的生物标志物:核苷(酸)类似物停药的前瞻性研究
J Infect Dis. 2025 Jun 2;231(5):1290-1298. doi: 10.1093/infdis/jiae541.
9
Guidance on treatment endpoints and study design for clinical trials aiming to achieve cure in chronic hepatitis B and D: Report from the 2022 AASLD-EASL HBV-HDV Treatment Endpoints Conference.慢性乙型和丁型肝炎临床治愈临床试验终点和研究设计指导:2022 年 AASLD-EASLHBV-HDV 治疗终点会议报告。
Hepatology. 2023 Nov 1;78(5):1654-1673. doi: 10.1097/HEP.0000000000000431. Epub 2023 Jun 21.
10
Safety and efficacy of GST-HG141, a novel HBV capsid assembly modulator, for the treatment of chronic hepatitis B patients with low-level viremia: a randomized, double-blind, placebo-controlled, multicenter phase II study.新型乙肝病毒衣壳组装调节剂GST-HG141治疗低病毒血症慢性乙型肝炎患者的安全性和有效性:一项随机、双盲、安慰剂对照、多中心II期研究
EClinicalMedicine. 2025 Aug 2;87:103400. doi: 10.1016/j.eclinm.2025.103400. eCollection 2025 Sep.

本文引用的文献

1
Long-term virological and clinical evaluation of chronic hepatitis B patients under nucleos(t)ide analogues therapy.接受核苷(酸)类似物治疗的慢性乙型肝炎患者的长期病毒学和临床评估。
Clin Res Hepatol Gastroenterol. 2025 Apr;49(4):102566. doi: 10.1016/j.clinre.2025.102566. Epub 2025 Mar 3.
2
Quantitative Change of Hepatitis B Surface Antigen Leading to Final Hepatitis B Surface Antigen Loss in Patients with Chronic Hepatitis B Receiving Nucleos(t)ide Analogs in China.中国接受核苷(酸)类似物治疗的慢性乙型肝炎患者中,乙肝表面抗原定量变化导致最终乙肝表面抗原消失的情况
Clin Transl Gastroenterol. 2025 Apr 1;16(4):e00820. doi: 10.14309/ctg.0000000000000820.
3
High accuracy model for HBsAg loss based on longitudinal trajectories of serum qHBsAg throughout long-term antiviral therapy.基于长期抗病毒治疗期间血清 qHBsAg 纵向轨迹的 HBsAg 丢失高精度模型。
Gut. 2024 Sep 9;73(10):1725-1736. doi: 10.1136/gutjnl-2024-332182.
4
Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy.经基于干扰素的联合疗法治疗后,慢性乙型肝炎患者 T 细胞功能得到恢复。
J Hepatol. 2016 Mar;64(3):539-46. doi: 10.1016/j.jhep.2015.10.013. Epub 2015 Oct 24.
5
Barodontalgia: in relation to scuba divers.气压牙痛:与水肺潜水员有关。
J Okla Dent Assoc. 1985 Spring;75(4):15-6.

Letter: Suggestions for Improving Study Design and Incorporating Virological Markers in HBV Functional Cure Research.

作者信息

Yang Chaoting, Shao Huaguo, Huang Jinsong

机构信息

The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China.

Institute of Hepatology and Epidemiology, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China.

出版信息

Clin Transl Gastroenterol. 2025 May 16;16(8):e00847. doi: 10.14309/ctg.0000000000000847. eCollection 2025 Aug 1.

DOI:10.14309/ctg.0000000000000847
PMID:40374181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12377330/
Abstract
摘要