SLA系统中分离畸变的初步证据。

Preliminary evidence of segregation distortion in the SLA system.

作者信息

Philipsen M, Kristensen B

出版信息

Anim Blood Groups Biochem Genet. 1985;16(2):125-33. doi: 10.1111/j.1365-2052.1985.tb01460.x.

DOI:10.1111/j.1365-2052.1985.tb01460.x

Abstract

The segregation of 11 well-defined SLA haplotypes was investigated in 40 Land-race and 48 Large White Danish and Swiss litters. Among the 11 haplotypes, the segregation of one (SLA 20-8.2.11) deviated significantly from the expected 1:1 segregation ratio in back-cross families. Tests indicated that these families were homogeneous with respect to segregation distortion, although the distortion was more pronounced in litters sired by heterozygous Danish boars than by heterozygous Swiss boars and Danish and Swiss sows. The data presented do not allow any definite conclusion about the cause of the segregation distortion. The possibility of the distortion being caused either by a complex similar to the T/t-complex found in mouse and contemplated in man or directly by the SLA region is discussed.

摘要

在40窝地方品种猪以及48窝丹麦大白猪和瑞士大白猪中，研究了11种明确的SLA单倍型的分离情况。在这11种单倍型中，有一种（SLA 20 - 8.2.11）在回交家系中的分离显著偏离预期的1:1分离比例。测试表明，这些家系在分离扭曲方面是同质的，尽管这种扭曲在由杂合丹麦公猪所生的仔猪中比由杂合瑞士公猪以及丹麦和瑞士母猪所生的仔猪中更为明显。所呈现的数据无法就分离扭曲的原因得出任何明确结论。文中讨论了分离扭曲是由类似于在小鼠中发现并在人类中考虑过的T/t复合体那样的复合体引起，还是直接由SLA区域引起的可能性。