McInnis B C, Deng L Z
Ann Biomed Eng. 1985;13(3-4):217-25. doi: 10.1007/BF02584240.
Control of arterial blood pressure has been successfully achieved by infusing a single vasoactive drug. However, in clinical practice, blood pressures are frequently controlled using multiple drug infusions. This paper presents a computer based adaptive control algorithm for simultaneous infusions of both an inotropic agent and a vasoactive agent to maintain the blood pressures at desired levels. We present the dynamics of the system with a bilinear two-input, two-output model. A least-squares parameter estimation algorithm has been employed using an output error method. Results of computer simulations of an electrical analog model of the heart and circulatory system are presented.
通过输注单一血管活性药物已成功实现动脉血压的控制。然而，在临床实践中，血压常常通过多种药物输注来控制。本文提出了一种基于计算机的自适应控制算法，用于同时输注强心剂和血管活性药物，以将血压维持在期望水平。我们用一个双线性双输入、双输出模型来描述该系统的动态特性。采用输出误差法的最小二乘参数估计算法。给出了心脏和循环系统电模拟模型的计算机模拟结果。
