The exposure of neural structures by removing the overlying bone using a high-speed drill can cause iatrogenic injury to the dura, neural tissue, and vessels. We investigated the safety and efficacy of a novel Surgify Safety Burr (SSB), attachable to existing high-speed drills. Three anesthetized living sheep underwent cranial burr hole drilling (n = 19) and hemilaminectomies (n = 14) with the SSB and standard burrs. Drilling time, dural injury, and subjective evaluation of heating and haptic feedback of each burr were assessed. Cranial burr hole drilling was done using diamond (n = 3), fluted (n = 6), and SSB (n = 10) burrs. Penetrating dura damage was observed in 33% of the diamond burr drilled holes, and in 33% of the fluted burr drilled holes, but not in the holes drilled with the SSB. Hemilaminectomies were performed with the SSB (n = 7) and diamond (n = 7) burrs without drilling-induced dura damage. Mean drilling time was not significantly different in cranial drilling (SSB, 121 ± 18s; fluted burr, 63 ± 22s; diamond burr, 165 ± 29s) nor in hemilaminectomy (SSB, 108 ± 13s; diamond burr, 95 ± 18s). Subjective evaluation of the SSB suggested efficient bone removal without heating or chattering. The SSB is a safe and effective surgical tool in cranial drilling and hemilaminectomy procedures. Safety, efficacy, and clinical benefits should be established in human studies.