巨噬细胞抑制在减轻减肥手术引起的非酒精性脂肪性肝炎中的作用
Macrophage inhibition in the alleviation of nonalcoholic steatohepatitis caused by bariatric surgery.
作者信息
Zheng Qianwen, Deng Shizhou, Chen Xiyu, Wang Yayun, Yang Yanling
机构信息
Department of Hepatobiliary Surgery, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Specific Lab for Mitochondrial Plasticity Underlying Nervous System Diseases, National Demonstration Center for Experimental Preclinical Medicine Education, The Fourth Military Medical University, Xi'an, 710032, China.
出版信息
Genes Immun. 2025 May 15. doi: 10.1038/s41435-025-00334-6.
The incidence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, and effective treatment is urgently needed. To understand the molecular mechanisms behind the effectiveness of bariatric surgery in treating NASH, we integrated single-cell and bulk RNA sequencing data to identify the role of liver macrophage polarization in alleviating NASH and screen possible drugs for treatment. Analysis revealed that bariatric surgery alleviates NASH by inhibiting liver M1 macrophage polarization with 12 differentially expressed M1 macrophage-related genes. Additionally, 56 potentially effective drugs were predicted for NASH treatment. These findings shed light on the effectiveness of bariatric surgery in treating NASH and offer potential drug candidates for further exploration.
非酒精性脂肪性肝炎（NASH）在全球的发病率正在上升，迫切需要有效的治疗方法。为了了解减肥手术治疗NASH有效性背后的分子机制，我们整合了单细胞和大量RNA测序数据，以确定肝脏巨噬细胞极化在缓解NASH中的作用，并筛选可能的治疗药物。分析表明，减肥手术通过抑制肝脏M1巨噬细胞极化来缓解NASH，其中有12个与M1巨噬细胞相关的差异表达基因。此外，还预测了56种对NASH治疗可能有效的药物。这些发现揭示了减肥手术治疗NASH的有效性，并为进一步探索提供了潜在的候选药物。
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