Molecular insights into ochratoxin A biodegradation.

Most of the agricultural products can potentially be exposed to mycotoxins-especially to ochratoxin A (OTA)-, which may cause foodborne diseases such as renal toxicity and notable economic losses worldwide. Biological detoxification is the most promising method to control OTA contamination. To provide a comprehensive understanding, this review summarizes the biodegradation pathways of OTA and discusses microbes capable of degrading OTA and their detoxification strategies. A detailed analysis of potentially useful enzymes for food and feed detoxification will be reported, highlighting specific enzymatic strategies identified in scientific literature. A comparative analysis of the functional capabilities of different OTA hydrolases demonstrates significant variation in degradation efficiency, thus the optimization of these enzymes is essential for the development of effective detoxification strategies. This review underscores the potential of harnessing these microorganisms and their enzymes for mitigating the toxic effects of OTA in contaminated environment and examining the essential requirements that must be met for the successful application of OTA degrading enzyme technology for promoting public health and food safety.