Berry D, Jobe A, Jacobs H, Ikegami M
Am Rev Respir Dis. 1985 Sep;132(3):500-3. doi: 10.1164/arrd.1985.132.3.500.
To investigate the ability of the preterm, ventilated lung to redirect blood flow away from atelectatic regions, we studied lambs with respiratory distress syndrome and spontaneous atelectasis or atelectasis caused by bronchial obstruction with a balloon catheter. Pulmonary blood flow distributions were measured by quantifying 15-mu, microsphere-associated radioactivity within multiple pieces of lung. Lambs with well aerated or very atelectatic lungs had relatively uniform blood flow/gram lung in all pieces of lung. Blood flow was much less uniform in lungs with both aerated and atelectatic regions. In 9 lambs with spontaneous atelectasis that included 25 +/- 5% (mean +/- SE) of the lungs by weight, blood flow was 29 +/- 4% less to atelectatic than to aerated lung volumes (p less than 0.01). In 5 lambs with well-aerated lungs, 18 +/- 3% of the lung by weight was made atelectatic by balloon occlusion of a major lower lobe bronchus. There was a 44 +/- 11% decrease in blood flow to the atelectatic lung segments. These studies document the ability of the lung of the premature, ventilated lamb to shunt pulmonary blood flow away from atelectatic lung volumes.
为了研究早产且接受通气的肺将血流从肺不张区域重新引流开的能力，我们对患有呼吸窘迫综合征且伴有自发性肺不张或由球囊导管阻塞支气管导致肺不张的羔羊进行了研究。通过对多块肺组织内与15微米微球相关的放射性进行定量来测量肺血流分布。肺通气良好或肺不张非常严重的羔羊，其所有肺组织中每克肺的血流相对均匀。在既有通气区域又有肺不张区域的肺中，血流的均匀性要差得多。在9只患有自发性肺不张的羔羊中，肺不张区域占肺重量的25±5%（平均值±标准误），肺不张区域的血流比通气区域的血流少29±4%（p<0.01）。在5只肺通气良好的羔羊中，通过球囊阻塞下叶主要支气管使占肺重量18±3%的肺区域发生肺不张。肺不张肺段的血流减少了44±11%。这些研究证明了早产且接受通气的羔羊的肺具有将肺血流从肺不张肺区域分流开的能力。
