Tryka A F, Sweeney T D, Brain J D, Godleski J J
Am Rev Respir Dis. 1985 Sep;132(3):606-11. doi: 10.1164/arrd.1985.132.3.606.
Regional clearance of submicrometric aerosol during 5 days was studied in control hamsters and in those with diffuse interstitial pulmonary fibrosis. Fibrosis was induced by treatment with bleomycin (1.6 U/kg) and oxygen (70% for 72 h) 80 days earlier. Diseased and control animals were exposed for 30 min to an insoluble colloidal 198Au aerosol (AMAD, 0.62 micron; sigma g, 1.35). Five diseased and 6 control animals were killed immediately (Day 0); 6 diseased and 6 control animals were killed 5 days later (Day 5). All lungs were excised, dried at TLC, sliced into 1-mm sections, and dissected into pieces. When compared with deposition in Day 0 control lungs, 26.3% of the particles had been cleared 5 days after exposure from the control lungs. Diseased animals cleared 44.6% of the particles (p less than 0.05, compared with Day 0 diseased animals). Examination of regional clearance on the basis of lobar differences, apex to base levels, and presence of airways also reflected increased clearance in the fibrotic animals. The parenchymal distribution of particle retention at Day 0 was less uniform in the fibrotic animals than in the control animals and was not significantly altered after 5 days of clearance in either group. Particle clearance may be greater in diseased lungs because of accelerated alveolar-bronchiolar transport of particles or particle-containing macrophages.
在对照仓鼠和患有弥漫性间质性肺纤维化的仓鼠中，研究了亚微米气溶胶在5天内的区域清除情况。纤维化是在80天前通过博来霉素（1.6 U/kg）和氧气（70%，持续72小时）治疗诱导产生的。患病动物和对照动物暴露于不溶性胶体198Au气溶胶30分钟（AMAD，0.62微米；σg，1.35）。5只患病动物和6只对照动物在暴露后立即处死（第0天）；6只患病动物和6只对照动物在5天后处死（第5天）。切除所有肺脏，在TLC下干燥，切成1毫米厚的切片，并切成小块。与第0天对照肺中的沉积相比，对照肺在暴露5天后26.3%的颗粒已被清除。患病动物清除了44.6%的颗粒（与第0天患病动物相比，p<0.05）。基于叶差异、尖部到基部水平以及气道存在情况对区域清除的检查也反映出纤维化动物的清除增加。在第0天，纤维化动物中颗粒滞留的实质分布比对照动物更不均匀，并且在两组清除5天后均未发生显著改变。患病肺中的颗粒清除可能更大，这是因为颗粒或含颗粒巨噬细胞的肺泡 - 细支气管转运加速。
