中国五省十县2019 - 2024年乙肝病毒母婴传播预防中疫苗接种后血清学检测的多地区流行病学评估
A Multi-Regional Epidemiological Evaluation on Post-vaccination Serological Testing in Prevention of Vertical Transmission of Hepatitis B Virus - 10 Counties, 5 Provinces, China, 2019-2024.
作者信息
Tang Lin, Li Lun, Huang Lifang, An Jing, Zhou Yang, Liu Yi, Liu Xiaoxue, Liu Qianqian, Wang Xiaoqi, Liu Siyu, Yang Hong, Wen Ning, Yin Zundong, Wang Fuzhen
机构信息
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease (NITFID), National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.
Department of National Immunization Program, Henan Provincial Center for Disease Control and Prevention, Zhengzhou City, Henan Province, China.
出版信息
China CDC Wkly. 2025 May 9;7(19):658-664. doi: 10.46234/ccdcw2025.108.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Post-vaccination serologic testing (PVST) of infants born to hepatitis B virus (HBV) infected mothers is important for evaluating effectiveness of strategies for preventing mother-to-child transmission (MTCT) of HBV.
WHAT IS ADDED BY THIS REPORT?: PVST was conducted in 43.7% of 7,425 infants born to HBV-infected mothers and showed that 0.8% of infants had breakthrough infections, indicating a very low level of prevention failure; anti-HBs positivity was 97.0% showing vaccine-induced protection; and 2.2% of HBV-exposed infants needed revaccination. Prevention failure was 12.7-fold higher among infants born to HBeAg-positive mothers.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: MTCT prevention strategy is highly effective. PVST evaluates MTCT prevention strategy and identifies infants needing revaccination; its use should be increased. Findings support WHO's HBV elimination strategy.
关于该主题已了解的信息
对乙型肝炎病毒（HBV）感染母亲所生婴儿进行疫苗接种后血清学检测（PVST）对于评估预防HBV母婴传播（MTCT）策略的有效性很重要。
本报告新增的内容
对7425名HBV感染母亲所生婴儿中的43.7%进行了PVST，结果显示0.8%的婴儿发生突破性感染，表明预防失败率非常低；抗-HBs阳性率为97.0%，表明疫苗诱导产生了保护作用；2.2%的HBV暴露婴儿需要重新接种疫苗。HBeAg阳性母亲所生婴儿的预防失败率高出12.7倍。
对公共卫生实践的启示
MTCT预防策略非常有效。PVST可评估MTCT预防策略并识别需要重新接种疫苗的婴儿；应增加其使用。研究结果支持世界卫生组织的HBV消除策略。
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