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透明质酸在种植体周围疾病治疗中的作用：一项荟萃分析的结果

Role of hyaluronic acid in the treatment of peri-implant diseases: results of a meta-analysis.

作者信息

López-Valverde Nansi, López-Valverde Antonio, Blanco Rueda José Antonio

机构信息

Department of Surgery, University of Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.

出版信息

Front Oral Health. 2025 May 1;6:1564599. doi: 10.3389/froh.2025.1564599. eCollection 2025.

DOI:10.3389/froh.2025.1564599
PMID:40376205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12078234/
Abstract

UNLABELLED

Peri-implantitis is an infectious-inflammatory disease that affects the tissues surrounding implants and is one of the main causes of implant failure. Hyaluronic acid (HA) is a natural polymer with multiple biomedical and cosmetic applications. The aim of this systematic review and meta-analysis was to evaluate its efficacy in the treatment of peri-implant disease.

METHODS

In accordance with PRISMA, the question was established: is HA treatment effective as a sole or adjunctive therapy for the treatment of peri-implantitis? PubMed/Medline, Embase, Cochrane Central, Dentistry & Oral Sciences Source and Web of Science were searched until December 2024. Inclusion criteria were interventional studies (RCTs and case series), according to the PICOs strategy in subjects with peri-implant pathology (participants), treated with HA (intervention) compared to conventionally treated or untreated patients (control) and assessing response to treatment (outcomes).

RESULTS

Thirty-two studies were obtained and four were selected. Risk of bias was assessed using the Cochrane Risk of Bias tool and methodological quality using the Joanna Briggs Institute tool. Meta-analysis of parameters was performed for pooled studies and for subgroups. The overall effect was in favour of the experimental group.

CONCLUSIONS

The use of HA as background or adjunctive therapy in peri-implantitis may be effective, although well-designed RCTs are warranted to validate the efficacy of the product.

SYSTEMATIC REVIEW REGISTRATION

Identifier (INPLANSY 2024100050).

摘要

未标注

种植体周围炎是一种感染性炎症疾病，会影响种植体周围组织，是种植体失败的主要原因之一。透明质酸（HA）是一种具有多种生物医学和美容应用的天然聚合物。本系统评价和荟萃分析的目的是评估其在治疗种植体周围疾病中的疗效。

方法

根据PRISMA，确定问题为：HA治疗作为种植体周围炎的单一或辅助治疗是否有效？检索了PubMed/Medline、Embase、Cochrane Central、牙科学与口腔科学资源库和Web of Science，检索截至2024年12月。纳入标准为干预性研究（随机对照试验和病例系列），根据PICOs策略，研究对象为患有种植体周围病变的受试者（参与者），接受HA治疗（干预），并与接受传统治疗或未治疗的患者（对照）进行比较，同时评估治疗反应（结果）。

结果

共获得32项研究，筛选出4项。使用Cochrane偏倚风险工具评估偏倚风险，使用乔安娜·布里格斯研究所工具评估方法学质量。对汇总研究和亚组进行参数的荟萃分析。总体结果有利于实验组。

结论

在种植体周围炎中使用HA作为基础或辅助治疗可能有效，尽管需要设计良好的随机对照试验来验证该产品的疗效。

系统评价注册

标识符（INPLANSY 2024100050）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/6a89eb2060d5/froh-06-1564599-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/5f20f76e26e9/froh-06-1564599-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/3e176ec03b58/froh-06-1564599-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/03fc476fa9e4/froh-06-1564599-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/7d8d60cd3d75/froh-06-1564599-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/d6cd8df7a7d3/froh-06-1564599-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/a78e103e7143/froh-06-1564599-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/1eac6b32709e/froh-06-1564599-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/613361207788/froh-06-1564599-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/6a89eb2060d5/froh-06-1564599-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/5f20f76e26e9/froh-06-1564599-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/3e176ec03b58/froh-06-1564599-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/03fc476fa9e4/froh-06-1564599-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/7d8d60cd3d75/froh-06-1564599-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/d6cd8df7a7d3/froh-06-1564599-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/a78e103e7143/froh-06-1564599-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/1eac6b32709e/froh-06-1564599-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/613361207788/froh-06-1564599-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8c3/12078234/6a89eb2060d5/froh-06-1564599-g009.jpg

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Dent J (Basel). 2024 Dec 17;12(12):414. doi: 10.3390/dj12120414.
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LONG-TERM PREDICTIVE VALUE OF BLEEDING ON PROBING IN PERI‑IMPLANTITIS DIAGNOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.探诊出血在种植体周围炎诊断中的长期预测价值：一项系统评价与Meta分析
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Reconstructive surgical therapy of peri-implant defects with ribose cross-linked collagen matrix and crosslinked hyaluronic acid - a prospective case series.
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Clin Oral Investig. 2024 Sep 20;28(10):536. doi: 10.1007/s00784-024-05942-6.
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