与短暂性全面性遗忘症相关的活化部分凝血活酶时间和凝血酶原时间短暂缩短。
Transient shortening of activated partial thromboplastin time and prothrombin time associated with transient global amnesia.
作者信息
Dziubek Dariusz, Dziubek Karolina, Stodolak Marcelina
机构信息
Deparment of Neurology, Holy Family Specjalistic Hospital, Rudna Mala, Poland.
Dentist, private practice, Rzeszow, Poland.
出版信息
Postep Psychiatr Neurol. 2025 Mar;34(1):54-57. doi: 10.5114/ppn.2025.149970. Epub 2025 Apr 30.
PURPOSE
Transient global amnesia (TGA) manifests as acute short-term memory disturbances lasting up to 24 hours. The pathophysiology of the disease remains unclear. This paper presents the case of a patient with recurrent TGA, in whom a shortening of coagulation times and high blood pressure peaks were observed during each acute phase of the disease, suggesting transient increased blood coagulability and transient dysregulation of autonomic blood pressure control.
CASE DESCRIPTION
A 59-year-old patient with medical history of migraine and arterial hypertension was diagnosed with recurrent TGA (two episodes within a year). Each time, upon admission to hospital, high blood pressure peaks were recorded and activated partial thromboplastin time (aPTT) and prothrombin time (PT) were shortened with gradual normalization over the following days.
COMMENT
The shortening of aPTT and PT may suggest a relationship between TGA and transient blood coagulation disorders in the acute phase.
目的
短暂性全面性遗忘症（TGA）表现为持续长达24小时的急性短期记忆障碍。该疾病的病理生理学仍不清楚。本文介绍了一例复发性TGA患者的病例，在该患者疾病的每个急性期均观察到凝血时间缩短和血压峰值升高，提示存在短暂性血液凝固性增加和自主血压控制的短暂失调。
病例描述
一名有偏头痛和动脉高血压病史的59岁患者被诊断为复发性TGA（一年内发作两次）。每次入院时均记录到血压峰值，活化部分凝血活酶时间（aPTT）和凝血酶原时间（PT）缩短，并在随后几天逐渐恢复正常。
评论
aPTT和PT缩短可能提示TGA与急性期短暂性血液凝固障碍之间存在关联。
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