Barakat Abdulrahman, Althahabi Rawan, Aljazaf Hanin, Hammadi Mariam, Alabbasi Mohamed, Alserdieh Faisal, Sharif Omar, Abubaker Faisal
Internal Medicine, King Hamad University Hospital, Muharraq, BHR.
Gastroenterology, King Hamad University Hospital, Muharraq, BHR.
Cureus. 2025 Apr 14;17(4):e82255. doi: 10.7759/cureus.82255. eCollection 2025 Apr.
Background and aims () is a significant cause of various gastrointestinal diseases, including gastritis, peptic ulcers, and even stomach cancer. Therefore, eradication is essential to prevent these conditions and their associated complications. The emergence of antibiotic-resistant strains and the lack of sufficient data on antibiotic sensitivity have made it increasingly challenging to treat , which has led to the emergence of various regimens. This article will compare the efficacy of different regimens to provide insights into the most effective treatment options for . Methods Our study is a retrospective, single-center study that reviews the data of 1,246 outpatients who were diagnosed with infection and underwent testing to confirm eradication of after receiving the therapeutic regimen. Patients received one of the following regimens: clarithromycin-based triple therapy (CT), levofloxacin-based triple therapy (LT), or bismuth-based quadruple therapy (BT). Results In total, 1,246 individuals were treated with different regimens, resulting in an overall success rate of 69.3%. The success rates of the triple and quadruple therapies were comparable, with 67.7% and 74.3%, respectively. When looking at individual treatment regimens, BT had the highest success rate at 74.3%, followed by CT with 67.9% and LT with 64.8%. Conclusion In Bahrain, BT demonstrates greater effectiveness compared to commonly used triple therapies. Despite this, the overall eradication rate remains low, indicating a significant presence of resistance within the population. Therefore, it is crucial to emphasize the need for sensitivity testing to develop local antibiograms and ensure cost-effectiveness.
背景与目的（幽门螺杆菌）是包括胃炎、消化性溃疡甚至胃癌在内的各种胃肠道疾病的重要病因。因此，根除幽门螺杆菌对于预防这些疾病及其相关并发症至关重要。抗生素耐药菌株的出现以及抗生素敏感性数据的不足使得幽门螺杆菌的治疗变得越来越具有挑战性，这导致了各种治疗方案的出现。本文将比较不同治疗方案的疗效，以深入了解幽门螺杆菌最有效的治疗选择。方法我们的研究是一项回顾性单中心研究，回顾了1246例被诊断为幽门螺杆菌感染并在接受治疗方案后进行检测以确认幽门螺杆菌根除情况的门诊患者的数据。患者接受以下治疗方案之一：基于克拉霉素的三联疗法（CT）、基于左氧氟沙星的三联疗法（LT）或基于铋剂的四联疗法（BT）。结果总共1246人接受了不同的治疗方案，总体成功率为69.3%。三联疗法和四联疗法的成功率相当，分别为67.7%和74.3%。在查看各个治疗方案时，BT的成功率最高，为74.3%，其次是CT，为67.9%，LT为64.8%。结论在巴林，与常用的三联疗法相比，BT显示出更高的有效性。尽管如此，总体根除率仍然较低，表明人群中存在显著的耐药性。因此，强调进行敏感性检测以制定当地的抗菌谱并确保成本效益至关重要。
