Villarreal Lihuén, Fontes-Silva Mateo, Mendaro Laura, Romanelli Gerardo, Benech Juan C
Plataforma de Microscopía de Fuerza Atómica, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Av. Italia, 3318, CP 11600 Montevideo, Uruguay.
Laboratorio de Señalización Celular y Nanobiología, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Av. Italia, 3318, CP 11600 Montevideo, Uruguay.
Biophys Rev. 2025 Apr 9;17(2):347-358. doi: 10.1007/s12551-025-01307-9. eCollection 2025 Apr.
According to the World Health Organization (WHO), cardiovascular diseases are the leading cause of death worldwide. Several diseases have been linked to changes in cellular mechanical properties, including those affecting the heart. Atomic force microscopy (AFM) has proven to be one of the most effective techniques for precisely determining the topography and mechanical properties of adherent living cells. In this review, we provide a short chronological overview of key studies conducted using AFM on cardiac cells or cardiomyocytes with clinical and medical significance. These studies have contributed and continue to enhance our understanding of the pathological processes affecting the heart and clarify the role of cell mechanics in cardiac and cardiovascular diseases.
根据世界卫生组织（WHO）的数据，心血管疾病是全球主要的死亡原因。几种疾病已与细胞力学特性的变化有关，包括那些影响心脏的疾病。原子力显微镜（AFM）已被证明是精确测定贴壁活细胞的形貌和力学特性的最有效技术之一。在这篇综述中，我们按时间顺序简要概述了使用AFM对具有临床和医学意义的心脏细胞或心肌细胞进行的关键研究。这些研究已经并将继续增进我们对影响心脏的病理过程的理解，并阐明细胞力学在心脏和心血管疾病中的作用。
