Evans G O
Ann Clin Biochem. 1985 Jul;22 ( Pt 4):397-401. doi: 10.1177/000456328502200412.
Some of the implications of method changes on data banks-for the effects of drugs on clinical laboratory tests are discussed. Using data from Wellcome Clinical Chemistry Quality Control Programmes, separated by a period of ten years, significant changes of methodology used by participants are illustrated. These changes are related to a recognised listing of drug effects in clinical chemistry tests available in 1975. It is suggested that information from external quality assessment schemes is used periodically to review the relevance of data in relation to major changes of methodology.
本文讨论了方法学变化对数据库的一些影响——关于药物对临床实验室检测的影响。利用来自威康临床化学质量控制计划、相隔十年的数据，展示了参与者所使用方法学的显著变化。这些变化与1975年可获得的临床化学检测中药物作用的公认列表相关。建议定期使用外部质量评估计划的信息，以审查与方法学重大变化相关的数据的相关性。
