Broccoli Alessandro, Zinzani Pier Luigi
Irccs Azienda ospedaliero-universitaria di Bologna, Policlinico Sant'Orsola-Malpighi, Istituto di Ematologia "L. e A. Seràgnoli", Bologna - Dipartimento di Scienze mediche e chirurgiche, Università di Bologna.
Recenti Prog Med. 2025 May;116(5):272-284. doi: 10.1701/4495.44947.
The aim of this work is to provide the information needed to adequately apply chimeric antigen receptor T-cell (CAR-T) therapy in real clinical practice in outpatient, day hospital and ward settings, with a particular focus on patients with diffuse large cell lymphoma and mantle cell lymphoma, which currently represent the main area of use of anti-CD19 CAR-T treatment. The currently approved indications in both contexts are reviewed and the fundamental steps to follow in starting CAR-T cell therapy are described, as well as the data available in the literature regarding each previously presented indication.
这项工作的目的是提供在门诊、日间医院和病房环境的实际临床实践中充分应用嵌合抗原受体T细胞（CAR-T）疗法所需的信息，特别关注弥漫性大B细胞淋巴瘤和套细胞淋巴瘤患者，这两种疾病目前是抗CD19 CAR-T治疗的主要应用领域。本文回顾了这两种情况下目前已获批的适应症，描述了启动CAR-T细胞治疗应遵循的基本步骤，以及文献中关于之前提及的各适应症的现有数据。
