Magot T
Ann Nutr Metab. 1985;29(3):175-83. doi: 10.1159/000176960.
A study has been carried out to measure the transfer rate of esterified cholesterol from the HDL into the chylomicrons, as previously suggested. Rats were intravenously injected with cholesterol-labelled plasma or red cells. The specific activity of esterified cholesterol of HDL and chylomicrons was measured during 12 h following injection. Results were treated by compartmental analysis. The transfer rate was 0.21-0.22 h-1 with an uptake rate of chylomicrons by the liver of 8 h-1 (t1/2 5 min). This represents a 0.8 mg h-1 flux of esterified cholesterol from HDL into chylomicrons, i.e., in our conditions, 75% of the total input into the chylomicrons esterified cholesterol. This process could be the major way for the disappearance of HDL esterified cholesterol.
如先前所述，已经开展了一项研究来测定酯化胆固醇从高密度脂蛋白（HDL）向乳糜微粒的转移速率。给大鼠静脉注射胆固醇标记的血浆或红细胞。在注射后的12小时内测定HDL和乳糜微粒中酯化胆固醇的比活性。结果采用房室分析进行处理。转移速率为0.21 - 0.22 h⁻¹，肝脏对乳糜微粒的摄取速率为8 h⁻¹（半衰期5分钟）。这代表酯化胆固醇从HDL向乳糜微粒的通量为0.8 mg h⁻¹，即在我们的实验条件下，占乳糜微粒酯化胆固醇总输入量的75%。这个过程可能是HDL酯化胆固醇消失的主要途径。
