Groothuizen Sam, van der Laken Conny Jacoba
Department of Rheumatology & Clinical Immunology, Amsterdam Institute for Infection & Immunity, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Curr Opin Rheumatol. 2025 Jul 1;37(4):282-288. doi: 10.1097/BOR.0000000000001098. Epub 2025 May 16.
Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Conventional imaging techniques are used to diagnose the disease and detect long-term structural changes. This review will assess molecular imaging in PsA, to evaluate its potential additive value over conventional and advanced anatomical imaging methods (e.g. ultrasound and MRI).
Current research is primarily focused on the molecular imaging technique PET/computed tomography (PET/CT) imaging, in which different tracers have been investigated. Fluorodeoxyglucose (FDG) can visualize disease activity and subclinical inflammation. New tracers targeting inflammatory sites have also been studied, such as FAPI (fibroblast activation protein inhibitor). Moreover, NaF (sodium fluoride) shows promise for imaging of new bone formation. Next to PET/CT, also fluorescence imaging and multispectral optoacoustic tomography have been investigated in the context of PsA.
Molecular imaging techniques hold promise for early diagnosis, monitoring and management of PsA. Future research is needed to define the role of molecular imaging relative to conventional and anatomical imaging techniques in patient care.
银屑病关节炎（PsA）是一种与银屑病相关的慢性炎症性疾病。传统成像技术用于诊断该疾病并检测长期结构变化。本综述将评估PsA中的分子成像，以评估其相对于传统和先进解剖成像方法（如超声和MRI）的潜在附加价值。
当前研究主要集中在分子成像技术正电子发射断层扫描/计算机断层扫描（PET/CT）成像上，其中已对不同的示踪剂进行了研究。氟脱氧葡萄糖（FDG）可以显示疾病活动和亚临床炎症。还研究了针对炎症部位的新型示踪剂，如成纤维细胞活化蛋白抑制剂（FAPI）。此外，氟化钠（NaF）在新骨形成成像方面显示出前景。除了PET/CT，荧光成像和多光谱光声断层扫描也已在PsA背景下进行了研究。
分子成像技术有望用于PsA的早期诊断、监测和管理。未来需要开展研究以确定分子成像相对于传统和解剖成像技术在患者护理中的作用。
