Bernikov A N, Govorov A V, Bagateliya Z A
FGBOU VO Russian University of Medicine, Moscow, Russia.
Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin, Moscow, Russia.
Urologiia. 2024 Dec(6):152-156.
Transrectal prostate biopsy remains the standard method for prostate cancer diagnosis, but it is associated with a high risk of infectious complications. In recent years, fosfomycin has been increasingly used as an alternative for antibiotic prophylaxis due to the increasing resistance of pathogens to fluoroquinolones, its good safety profile and ease of use. Results of several studies dedicated to the efficiency of fosfomycin are highlighted in this review. Fosfomycin demonstrates significant advantages as a drug for the prevention of infectious and inflammatory complications in patients after prostate biopsy, especially in case of increasing resistance to fluoroquinolones. Its efficacy, safety and ease of use make it an attractive choice and a reliable alternative in the context of increasing antibiotic resistance. Combination regimens with fluoroquinolones may be preferable for high-risk group.
经直肠前列腺活检仍然是前列腺癌诊断的标准方法，但它与感染性并发症的高风险相关。近年来，由于病原体对氟喹诺酮类药物的耐药性增加、磷霉素良好的安全性和易用性，磷霉素越来越多地被用作抗生素预防的替代药物。本综述强调了几项关于磷霉素疗效的研究结果。磷霉素作为预防前列腺活检后患者感染性和炎症性并发症的药物具有显著优势，尤其是在对氟喹诺酮类药物耐药性增加的情况下。其疗效、安全性和易用性使其在抗生素耐药性增加的背景下成为有吸引力的选择和可靠的替代药物。对于高危人群，氟喹诺酮类药物联合用药方案可能更可取。
