Galaburda A M, Sherman G F, Rosen G D, Aboitiz F, Geschwind N
Ann Neurol. 1985 Aug;18(2):222-33. doi: 10.1002/ana.410180210.
We report the neuroanatomical findings in 4 consecutively studied brains of men with developmental dyslexia. The patients, who ranged in age between 14 and 32 years, were diagnosed as dyslexic during life. Nonrighthandedness and several autoimmune and atopic illnesses were present in the personal and family histories. All brains showed developmental anomalies of the cerebral cortex. These consisted of neuronal ectopias and architectonic dysplasias located mainly in perisylvian regions and affecting predominantly the left hemisphere. Furthermore, all brains showed a deviation from the standard pattern of cerebral asymmetry characterized by symmetry of the planum temporale. The neuroanatomical findings in these 4 patients are discussed with reference to developmental cortical anomalies, cerebral asymmetries, reorganization of the brain after early lesions, and the association between learning disorders, left handedness, and diseases of the immune system.
我们报告了对4名患有发育性阅读障碍男性的连续研究大脑的神经解剖学发现。这些患者年龄在14至32岁之间，在生前被诊断为阅读障碍。个人史和家族史中存在非右利手以及多种自身免疫性和特应性疾病。所有大脑均显示出大脑皮质的发育异常。这些异常包括神经元异位和结构发育异常，主要位于颞叶周围区域，且主要影响左半球。此外，所有大脑均表现出偏离以颞平面对称性为特征的大脑不对称标准模式。结合发育性皮质异常、大脑不对称、早期损伤后脑的重组以及学习障碍、左利手和免疫系统疾病之间的关联，对这4例患者的神经解剖学发现进行了讨论。
