Hulin Margot, Le Seac'h Agathe, Jaume Léa, Seneschal Julien, Boniface Katia, Barbaud Annick, Mathian Alexis, Amoura Zahir, Chasset François
Department of Dermatology and Allergology, Hôpital Tenon, Paris, France.
Faculté de Médecine, Sorbonne Université, Paris, France.
Lupus. 2025 Jun;34(7):761-763. doi: 10.1177/09612033251345017. Epub 2025 May 16.
We report two cases of patients with refractory discoid lupus erythematosus (DLE) and dark skin phototypes who experienced progressive perifollicular repigmentation of depigmented lesions under anifrolumab therapy, with sustained improvement over 18 months. These observations highlight a potential novel effect of anifrolumab on cicatricial dyspigmentation in DLE. This effect may represent a valuable therapeutic option for DLE-related damage, particularly in patients with darker skin types.
我们报告了两例难治性盘状红斑狼疮（DLE）且皮肤光型较深的患者，他们在接受阿尼鲁单抗治疗后，色素脱失性皮损出现了进行性毛囊周围色素再沉着，且在18个月内持续改善。这些观察结果突出了阿尼鲁单抗对DLE瘢痕性色素沉着异常的潜在新作用。这种作用可能是DLE相关损伤的一种有价值的治疗选择，特别是对于皮肤类型较深的患者。
