Rohlfing B M
AJR Am J Roentgenol. 1977 Apr;128(4):599-600. doi: 10.2214/ajr.128.4.599.
Center vertebral end-plate depression was originally reported to be pathognomonic for sickle cell disease. Two patients without hemoglobinopathy were found to have this deformity. One patient has congenital hereditary spherocytosis; the other has no blood dyscrasia but is osteopenic. Therefore, although this deformity is usually due to sickle cell disease, it is not pathognomonic.
椎体终板凹陷最初被报道为镰状细胞病的特征性表现。发现两名无血红蛋白病的患者有这种畸形。一名患者患有先天性遗传性球形红细胞增多症；另一名患者无血液系统异常，但有骨质减少。因此，尽管这种畸形通常由镰状细胞病引起，但并非其特征性表现。
