Tham See Wan, Lee Rebecca, Rau Lisa-Marie, Sethna Navil Firoze, Nylander Elisabeth Mueller, Fabrizi Lorenzo, Wager Julia, Koechlin Helen
Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, USA.
BMJ Open. 2025 May 16;15(5):e101963. doi: 10.1136/bmjopen-2025-101963.
There are no validated paediatric-specific diagnostic criteria for complex regional pain syndrome (CRPS). As a result, diagnostic tools developed for adults (eg, Budapest Criteria, Japanese Diagnostic Criteria, Veldman Criteria) are frequently applied in the paediatric population. However, the clinical presentations and trajectories of children can differ from adults. Given that treatment outcomes are linked to early diagnosis and intervention, the lack of paediatric-specific screening or diagnostic tools is an important knowledge gap. We aim to identify the frequency of individual criteria used in diagnosing CRPS in children and adolescents in existing literature, summarise assessment methods used to establish the diagnosis, and provide recommendations for research and clinical application.
The following databases and platforms will be searched for articles published from 2003 (year the Budapest Criteria was developed) onward: CINAHL, CENTRAL, Embase, Ovid MEDLINE, PubMed, PsycINFO and Web of Science. Our search strategy will use subject headings and text words related to the concepts of CRPS in paediatric populations, with study inclusion criteria from birth up to 18 years old, and a diagnosis of CRPS. Data will be extracted by our multidisciplinary team and findings will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews.
This study does not involve human participants or unpublished data; therefore, approval from a human research ethics committee is not required. The findings of this scoping review will be disseminated through academic conferences and peer-reviewed publications.
目前尚无经过验证的针对儿童复杂性区域疼痛综合征（CRPS）的特定诊断标准。因此，为成人开发的诊断工具（如布达佩斯标准、日本诊断标准、韦尔德曼标准）经常应用于儿科人群。然而，儿童的临床表现和病程可能与成人不同。鉴于治疗结果与早期诊断和干预相关，缺乏针对儿童的筛查或诊断工具是一个重要的知识空白。我们旨在确定现有文献中用于诊断儿童和青少年CRPS的各个标准的频率，总结用于确立诊断的评估方法，并为研究和临床应用提供建议。
将检索以下数据库和平台，以查找2003年（布达佩斯标准制定年份）以来发表的文章：CINAHL、CENTRAL、Embase、Ovid MEDLINE、PubMed、PsycINFO和Web of Science。我们的检索策略将使用与儿科人群中CRPS概念相关的主题词和文本词，研究纳入标准为从出生到18岁，且诊断为CRPS。数据将由我们的多学科团队提取，研究结果将按照系统评价和Meta分析扩展版的首选报告项目（PRISMA-ScR）进行报告。
本研究不涉及人类参与者或未发表的数据；因此，无需获得人类研究伦理委员会的批准。本范围综述的结果将通过学术会议和同行评审出版物进行传播。
