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白血病治疗中的纳米技术:革新靶向药物递送与免疫调节

Nanotechnology in leukemia therapy: revolutionizing targeted drug delivery and immune modulation.

作者信息

Bishoyi Ashok Kumar, Nouri Sina, Hussen Ahmed, Bayani Alireza, Khaksari Mohammad Navid, Soleimani Samarkhazan Hamed

机构信息

Department of Microbiology, Marwadi University Research Center, Faculty of Science, Marwadi University, Rajkot, Gujarat, 360003, India.

Department of Immunology, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.

出版信息

Clin Exp Med. 2025 May 17;25(1):166. doi: 10.1007/s10238-025-01686-z.

Abstract

Leukemia, a group of blood cancers, presents a significant global health challenge. Despite advancements in conventional therapies like chemotherapy and immunotherapy, the need for more effective and less toxic treatments remains. Nanotechnology offers a promising avenue for targeted drug delivery and immune modulation in the fight against leukemia. Through the utilization of nanomaterials' special qualities, like their small size, large surface area, and capacity to transport a variety of payloads, scientists are creating novel ways to get around the drawbacks of conventional treatments. These strategies include targeted drug delivery, immune cell activation, and overcoming drug resistance. However, challenges remain in translating these promising nanotechnological approaches into clinical applications. Addressing issues such as toxicity, biodistribution, and regulatory hurdles is crucial for the successful development of nanomedicine for leukemia. In conclusion, nanotechnology offers a promising future for the treatment of leukemia. Continued research and development are essential to unlock the full potential of nanomaterials and improve patient outcomes. The potential of nanotechnology-based strategies to improve the effectiveness of leukemia treatments is explored in this review. We go over the function of different nanomaterials in delivering therapeutic agents to leukemia cells, such as liposomes, polymeric nanoparticles, and inorganic anoparticles. We also investigate the engineering of nanomaterials to influence the immune system and promote anti-tumor reactions.

摘要

白血病是一类血癌,对全球健康构成重大挑战。尽管化疗和免疫疗法等传统疗法取得了进展,但仍需要更有效且毒性更小的治疗方法。纳米技术为抗击白血病中的靶向药物递送和免疫调节提供了一条有前景的途径。通过利用纳米材料的特殊性质,如它们的小尺寸、大表面积以及运输各种有效载荷的能力,科学家们正在创造新方法来克服传统治疗的缺点。这些策略包括靶向药物递送、免疫细胞激活以及克服耐药性。然而,将这些有前景的纳米技术方法转化为临床应用仍面临挑战。解决毒性、生物分布和监管障碍等问题对于白血病纳米医学的成功开发至关重要。总之,纳米技术为白血病治疗提供了一个有前景的未来。持续的研发对于释放纳米材料的全部潜力和改善患者预后至关重要。本综述探讨了基于纳米技术的策略改善白血病治疗效果的潜力。我们回顾了不同纳米材料在将治疗剂递送至白血病细胞中的作用,如脂质体、聚合物纳米颗粒和无机纳米颗粒。我们还研究了纳米材料的工程设计,以影响免疫系统并促进抗肿瘤反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48c/12084282/704dbdebd2b8/10238_2025_1686_Fig1_HTML.jpg

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