Putman S F, Adams H P
Arch Neurol. 1985 Oct;42(10):960-2. doi: 10.1001/archneur.1985.04060090042011.
We evaluated the efficacy of short-term intravenous heparin therapy in 74 patients with recent transient ischemic attacks (TIAs). The patients were treated after hospitalization until operation or long-term medical treatment was instituted. Heparin was given in a continuous infusion to maintain an activated partial thromboplastin time of 1 1/2 to 2 1/2 times control values. During the treatment period, 12 patients (16.2%) had recurrent TIAs and five (6.8%) had cerebral infarction. Bleeding complications occurred in nine patients (12.2%). In this limited series, heparin did not prevent recurrent TIAs or cerebral infarction among high-risk patients with recent TIAs.
我们评估了短期静脉注射肝素疗法对74例近期发生短暂性脑缺血发作（TIA）患者的疗效。患者入院后接受治疗，直至进行手术或开始长期药物治疗。肝素持续静脉输注，以维持活化部分凝血活酶时间为对照值的1.5至2.5倍。在治疗期间，12例患者（16.2%）出现TIA复发，5例（6.8%）发生脑梗死。9例患者（12.2%）出现出血并发症。在这个有限的系列研究中，肝素未能预防近期发生TIA的高危患者出现TIA复发或脑梗死。
