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不同糖代谢状态下纤维蛋白原/白蛋白比值及卡斯泰利风险指数2（CRI-2 =低密度脂蛋白胆固醇/高密度脂蛋白胆固醇）与冠状动脉病变严重程度的相关性

Association of fibrinogen/albumin ratio and Castelli risk index 2 (CRI-2=LDL-C/HDL-C) with severity of coronary artery lesions in different glucose metabolism states.

作者信息

Liu Yue, Jin Xiandu, Jia Wenjun, Guan Xiuju, Wu Hao, Li Jiao, Cui Min, Zhang Hanmo, Wei Liping, Qi Xin

机构信息

Department of Cardiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.

School of Medicine, Nankai University, Tianjin, China.

出版信息

Endocrine. 2025 May 17. doi: 10.1007/s12020-025-04259-y.

DOI:10.1007/s12020-025-04259-y

PMID:40381131

Abstract

BACKGROUND

The fibrinogen to albumin ratio (FAR) is a novel inflammatory indicator correlating with the severity of coronary artery disease (CAD). An indicator of atherosclerosis is the Castelli Risk Index 2 (CRI-2=LDL-C/HDL-C). Yet, little research has focused on the link between both of indicators and CAD in different glucose metabolic states. Thus, this study aimed to investigate the association between FAR, CRI-2, and the severity of coronary artery lesions in patients with CAD in different glucose metabolic states.

METHOD

In this investigation, coronary angiography was performed about 2825 individuals suffering from symptomatic CAD at Tianjin Union Medical Center from 2016-2023.The number of stenotic arteries in the coronary arteries was counted. The Gensini scores were taken into account. Normal glucose regulation (NGR), pre-diabetes mellitus (Pre-DM), and diabetes mellitus (DM) were the three categories of glucose status according to the WHO diabetes guidelines. Patients were also divided into FAR index and CRI-2 quartiles to look into the link between FAR index and CRI-2 and coronary artery lesions in CAD patients with different glucose metabolic states. Receiver operating characteristic (ROC) curves were constructed to analyze the predictive value of the FAR index and CRI-2 for coronary artery lesions.

RESULT

According to logistic regression analysis, the FAR index and CRI-2 were statistically associated with coronary artery disease (P < 0.05). The FAR index was linked with severity of coronary artery lesions regardless of glucose metabolism states (P < 0.05). The CRI-2 was strongly linked with severity of coronary artery lesions in both NGR and DM status (P < 0.05). Yet, there was no statistical significance in Pre-DM states (P > 0.05). The FAR index and CRI-2 exhibited higher regions underneath the ROC curve in forecasting severity of coronary artery lesions.

CONCLUSION

The FAR index and CRI-2 were significantly associated with severity of coronary artery lesions in different glucose metabolic states. FAR index and CRI-2 have predictive value for coronary artery lesions.

摘要

背景

纤维蛋白原与白蛋白比值（FAR）是一种与冠状动脉疾病（CAD）严重程度相关的新型炎症指标。动脉粥样硬化的一个指标是卡斯泰利风险指数2（CRI-2 =低密度脂蛋白胆固醇/高密度脂蛋白胆固醇）。然而，很少有研究关注这两个指标与不同糖代谢状态下CAD之间的联系。因此，本研究旨在探讨FAR、CRI-2与不同糖代谢状态下CAD患者冠状动脉病变严重程度之间的关联。

方法

在本次调查中，2016年至2023年期间，对天津医科大学总医院2825例有症状的CAD患者进行了冠状动脉造影。统计冠状动脉中狭窄动脉的数量。考虑了Gensini评分。根据世界卫生组织糖尿病指南，正常血糖调节（NGR）、糖尿病前期（Pre-DM）和糖尿病（DM）是三种血糖状态类别。患者还被分为FAR指数和CRI-2四分位数，以研究FAR指数和CRI-2与不同糖代谢状态的CAD患者冠状动脉病变之间的联系。构建受试者工作特征（ROC）曲线，分析FAR指数和CRI-2对冠状动脉病变的预测价值。

结果

根据逻辑回归分析，FAR指数和CRI-2与冠状动脉疾病在统计学上相关（P < 0.05）。无论糖代谢状态如何，FAR指数都与冠状动脉病变的严重程度相关（P < 0.05）。在NGR和DM状态下，CRI-2与冠状动脉病变的严重程度密切相关（P < 0.05）。然而，在糖尿病前期状态下没有统计学意义（P > 0.05）。FAR指数和CRI-2在预测冠状动脉病变严重程度方面表现出较高的ROC曲线下面积。