Qu Na, Li Qian, Bai Xin, Wang Ruixiao
Department of Internal Medicine, Ningxia People's Armed Police Corps Hospital, Yinchuan, Ningxia Hui Autonomous Region, China.
Department of Pathology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Br J Hosp Med (Lond). 2025 Jun 25;86(6):1-16. doi: 10.12968/hmed.2024.1038. Epub 2025 Jun 13.
This study aimed to examine the relationship between coronary heart disease (CHD) severity, the triglyceride-glucose (TyG) index, and the total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio while also assessing their diagnostic significance. A deeper understanding of the pathophysiology of CHD enables early detection, more precise screening of high-risk groups, and the development of more targeted treatment plans. A total of 196 patients with suspected acute coronary syndrome (ACS) were included in this retrospective study, of whom 134 were diagnosed with CHD. Clinical, laboratory and coronary angiography (CAG) data were collected. CHD patients were classified into low-, medium-, and high-risk groups according to their Synergy Between Percutaneous Coronary Intervention (PCI) with Taxus and Cardiac Surgery (SYNTAX) scores. The correlations and clinical relevance of the TyG index and TC/HDL-C ratio were further examined by stratifying patients into single-, dual-, and multi-vessel groups according to the number of lesions. A -value < 0.05 was considered statistically significant. Relative to non-CHD patients, CHD patients were significantly older and exhibited higher levels of TC, Triglycerides (TG), TyG index, and TC/HDL-C ratio ( < 0.05). Both the TyG index and TC/HDL-C ratio were independently associated with the risk of coronary atherosclerosis in univariate and multivariate logistic regression analyses ( < 0.05). The multi-vessel disease group had significantly higher TyG index and TC/HDL-C ratio values compared to the single- and dual-vessel groups ( < 0.05). Additionally, SYNTAX scores showed a significantly positive correlation with both indices ( < 0.05). The area under the curve (AUC) values for the TC/HDL-C ratio and TyG index were 0.918 and 0.893, respectively, both significantly greater than 0.5 ( < 0.05). The TC/HDL-C ratio and TyG index are associated with the risk of CHD, with their values rising as coronary artery disease severity progresses. These indices may serve as valuable tools for predicting clinical severity in patients with coronary artery lesions.
本研究旨在探讨冠心病（CHD）严重程度、甘油三酯-葡萄糖（TyG）指数与总胆固醇与高密度脂蛋白胆固醇（TC/HDL-C）比值之间的关系，并评估它们的诊断意义。深入了解冠心病的病理生理学有助于早期发现、更精确地筛查高危人群以及制定更具针对性的治疗方案。本回顾性研究共纳入196例疑似急性冠状动脉综合征（ACS）患者，其中134例被诊断为冠心病。收集了临床、实验室及冠状动脉造影（CAG）数据。冠心病患者根据其经皮冠状动脉介入治疗（PCI）与心脏手术（SYNTAX）评分的协同作用分为低、中、高风险组。根据病变数量将患者分为单支、双支和多支血管组，进一步研究TyG指数和TC/HDL-C比值的相关性及临床意义。P值<0.05被认为具有统计学意义。与非冠心病患者相比，冠心病患者年龄显著更大，且总胆固醇（TC）、甘油三酯（TG）、TyG指数和TC/HDL-C比值水平更高（P<0.05）。在单因素和多因素逻辑回归分析中，TyG指数和TC/HDL-C比值均与冠状动脉粥样硬化风险独立相关（P<0.05）。与单支和双支血管组相比，多支血管病变组的TyG指数和TC/HDL-C比值显著更高（P<0.05）。此外，SYNTAX评分与这两个指标均呈显著正相关（P<0.05）。TC/HDL-C比值和TyG指数的曲线下面积（AUC）值分别为0.918和0.893，均显著大于0.5（P<0.05）。TC/HDL-C比值和TyG指数与冠心病风险相关，随着冠状动脉疾病严重程度的进展，其值升高。这些指标可能是预测冠状动脉病变患者临床严重程度的有价值工具。
